KCNG1

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Potassium voltage-gated channel, subfamily G, member 1
Identifiers
Symbol(s) KCNG1; K13; KCNG; KV6.1; MGC12878; kH2
External IDs OMIM: 603788 MGI: 3616086 HomoloGene: 20515
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3755 241794
Ensembl ENSG00000026559 ENSMUSG00000074575
Uniprot Q9UIX4 n/a
Refseq NM_002237 (mRNA)
NP_002228 (protein)		 XM_141545 (mRNA)
XP_141545 (protein)
Location Chr 20: 49.05 - 49.07 Mb Chr 2: 167.95 - 167.96 Mb
Pubmed search [1] [2]

Potassium voltage-gated channel, subfamily G, member 1, also known as KCNG1 or Kv6.1, is a human gene.[1]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Alternative splicing results in at least two transcript variants encoding distinct isoforms.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: KCNG1 potassium voltage-gated channel, subfamily G, member 1.

[edit] Further reading

  • Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.". Pharmacol. Rev. 57 (4): 473-508. doi:10.1124/pr.57.4.10. PMID 16382104. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Su K, Kyaw H, Fan P, et al. (1998). "Isolation, characterization, and mapping of two human potassium channels.". Biochem. Biophys. Res. Commun. 241 (3): 675-81. doi:10.1006/bbrc.1997.7830. PMID 9434767. 
  • Post MA, Kirsch GE, Brown AM (1997). "Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current.". FEBS Lett. 399 (1-2): 177-82. PMID 8980147. 

[edit] External links

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Membrane transport protein: ion channels
Ca2+: Calcium channel
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel
K+: Potassium channel
Cl-: Chloride channel
Porin
Cations: TRP
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
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