KCNE4

From Wikipedia, the free encyclopedia

Potassium voltage-gated channel, Isk-related family, member 4

Identifiers

KCNE4; MGC20353; MIRP3

External IDs

OMIM: 607775 MGI: 1891125 HomoloGene: 10959

Gene ontology
Molecular Function:	• voltage-gated potassium channel activity • potassium ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• ion transport • potassium ion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_080671 (mRNA)
NP_542402 (protein)

NM_021342 (mRNA)
NP_067317 (protein)

Location

Chr 2: 223.63 - 223.63 Mb

Chr 1: 78.7 - 78.7 Mb

Pubmed search

[1]

[2]

Potassium voltage-gated channel, Isk-related family, member 4, also known as KCNE4, is a human gene.^[1]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus.^[1]

[edit] References

^ ^a ^b Entrez Gene: KCNE4 potassium voltage-gated channel, Isk-related family, member 4.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Abbott GW, Sesti F, Splawski I, et al. (1999). "MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia.". Cell 97 (2): 175–87. PMID 10219239.
Grunnet M, Jespersen T, Rasmussen HB, et al. (2003). "KCNE4 is an inhibitory subunit to the KCNQ1 channel.". J. Physiol. (Lond.) 542 (Pt 1): 119–30. PMID 12096056.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Teng S, Ma L, Zhen Y, et al. (2003). "Novel gene hKCNE4 slows the activation of the KCNQ1 channel.". Biochem. Biophys. Res. Commun. 303 (3): 808–13. PMID 12670483.
Grunnet M, Rasmussen HB, Hay-Schmidt A, et al. (2004). "KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.". Biophys. J. 85 (3): 1525–37. PMID 12944270.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Grunnet M, Olesen SP, Klaerke DA, Jespersen T (2005). "hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.". Biochem. Biophys. Res. Commun. 328 (4): 1146–53. doi:10.1016/j.bbrc.2005.01.071. PMID 15707997.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Lundquist AL, Turner CL, Ballester LY, George AL (2006). "Expression and transcriptional control of human KCNE genes.". Genomics 87 (1): 119–28. doi:10.1016/j.ygeno.2005.09.004. PMID 16303284.
Zeng Z, Tan C, Teng S, et al. (2007). "The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population.". Cardiology 108 (2): 97–103. doi:10.1159/000095943. PMID 17016049.