KCNC1

From Wikipedia, the free encyclopedia


Potassium voltage-gated channel, Shaw-related subfamily, member 1
Identifiers
Symbol(s) KCNC1; KV3.1; KV4; MGC129855; NGK2
External IDs OMIM: 176258 MGI: 96667 HomoloGene: 68134
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3746 16502
Ensembl ENSG00000129159 ENSMUSG00000058975
Uniprot P48547 Q3UHB6
Refseq NM_004976 (mRNA)
NP_004967 (protein)		 NM_008421 (mRNA)
NP_032447 (protein)
Location Chr 11: 17.71 - 17.75 Mb Chr 7: 46.26 - 46.31 Mb
Pubmed search [1] [2]

Potassium voltage-gated channel, Shaw-related subfamily, member 1, also known as KCNC1 or Kv3.1, is a human gene.[1]

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: KCNC1 potassium voltage-gated channel, Shaw-related subfamily, member 1.

[edit] Further reading

  • Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Devaux J, Alcaraz G, Grinspan J, et al. (2003). "Kv3.1b is a novel component of CNS nodes.". J. Neurosci. 23 (11): 4509–18. PMID 12805291. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7986–91. doi:10.1073/pnas.122617999. PMID 12060745. 
  • Ried T, Rudy B, Vega-Saenz de Miera E, et al. (1993). "Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15.". Genomics 15 (2): 405–11. PMID 8449507. 
  • Xu J, Yu W, Jan YN, et al. (1995). "Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits.". J. Biol. Chem. 270 (42): 24761–8. PMID 7559593. 
  • Grissmer S, Ghanshani S, Dethlefs B, et al. (1992). "The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells.". J. Biol. Chem. 267 (29): 20971–9. PMID 1400413. 

[edit] External links

 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel
K+: Potassium channel
Cl-: Chloride channel
Porin
Cations: TRP
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Other/general