KATNB1

From Wikipedia, the free encyclopedia

Katanin p80 (WD repeat containing) subunit B 1

Identifiers

External IDs

OMIM: 602703 MGI: 1921437 HomoloGene: 4302

Gene ontology
Molecular Function:	• microtubule binding • microtubule-severing ATPase activity • protein heterodimerization activity
Cellular Component:	• spindle pole • cytoplasm • cytoskeleton • microtubule • katanin complex
Biological Process:	• protein targeting • negative regulation of microtubule depolymerization • cell cycle • mitosis • positive regulation of microtubule depolymerization • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005886 (mRNA)
NP_005877 (protein)

NM_028805 (mRNA)
NP_083081 (protein)

Location

Chr 16: 56.33 - 56.35 Mb

Chr 8: 97.97 - 97.99 Mb

Pubmed search

[1]

[2]

Katanin p80 (WD repeat containing) subunit B 1, also known as KATNB1, is a human gene.^[1]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.^[1]

[edit] References

^ ^a ^b Entrez Gene: KATNB1 katanin p80 (WD repeat containing) subunit B 1.

[edit] Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Toyo-Oka K, Sasaki S, Yano Y, et al. (2006). "Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.". Hum. Mol. Genet. 14 (21): 3113-28. doi:10.1093/hmg/ddi339. PMID 16203747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Karabay A, Yu W, Solowska JM, et al. (2004). "Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules.". J. Neurosci. 24 (25): 5778-88. doi:10.1523/JNEUROSCI.1382-04.2004. PMID 15215300.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
McNally KP, Bazirgan OA, McNally FJ (2000). "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin.". J. Cell. Sci. 113 ( Pt 9): 1623-33. PMID 10751153.
Ahmad FJ, Yu W, McNally FJ, Baas PW (1999). "An essential role for katanin in severing microtubules in the neuron.". J. Cell Biol. 145 (2): 305-15. PMID 10209026.
McNally FJ, Thomas S (1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs.". Mol. Biol. Cell 9 (7): 1847-61. PMID 9658175.
Hartman JJ, Mahr J, McNally K, et al. (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.". Cell 93 (2): 277-87. PMID 9568719.
McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes.". J. Cell. Sci. 109 ( Pt 3): 561-7. PMID 8907702.
McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules.". Cell 75 (3): 419-29. PMID 8221885.
Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions.". Mol. Cell. Biol. 3 (10): 1738-45. PMID 6646120.