KATNA1

From Wikipedia, the free encyclopedia

Katanin p60 (ATPase-containing) subunit A 1

Identifiers

External IDs

OMIM: 606696 MGI: 1344353 HomoloGene: 56014

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding • microtubule binding • microtubule-severing ATPase activity • hydrolase activity • ATPase activity • dynein binding • protein heterodimerization activity
Cellular Component:	• spindle pole • nucleus • lipid particle • centrosome • microtubule • plasma membrane • axon
Biological Process:	• neuron migration • cell cycle • mitosis • protein localization • cytoplasmic microtubule organization and biogenesis • cell division • interphase of mitotic cell cycle

Orthologs

Human

Mouse

Refseq

NM_007044 (mRNA)
NP_008975 (protein)

NM_011835 (mRNA)
NP_035965 (protein)

Location

Chr 6: 149.96 - 150.01 Mb

Chr 10: 7.42 - 7.45 Mb

Pubmed search

[1]

[2]

Katanin p60 (ATPase-containing) subunit A 1, also known as KATNA1, is a human gene.^[1]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.^[1]

[edit] References

^ ^a ^b Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1.

[edit] Further reading

McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules.". Cell 75 (3): 419–29. PMID 8221885.
McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes.". J. Cell. Sci. 109 ( Pt 3): 561–7. PMID 8907702.
Hartman JJ, Mahr J, McNally K, et al. (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.". Cell 93 (2): 277–87. PMID 9568719.
McNally FJ, Thomas S (1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs.". Mol. Biol. Cell 9 (7): 1847–61. PMID 9658175.
Ahmad FJ, Yu W, McNally FJ, Baas PW (1999). "An essential role for katanin in severing microtubules in the neuron.". J. Cell Biol. 145 (2): 305–15. PMID 10209026.
Syu LJ, Saltiel AR (1999). "Lipotransin: a novel docking protein for hormone-sensitive lipase.". Mol. Cell 4 (1): 109–15. PMID 10445032.
McNally KP, Bazirgan OA, McNally FJ (2000). "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin.". J. Cell. Sci. 113 ( Pt 9): 1623–33. PMID 10751153.
Buster D, McNally K, McNally FJ (2002). "Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis.". J. Cell. Sci. 115 (Pt 5): 1083–92. PMID 11870226.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.