User:Karengreen1971
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One British woman, Karen, had encountered removing womb that she was unable to fertility. The marriage would collapse. British scientist Professor Christopher, London hospital, sympathized and helped them, tried to use a new technology –ecology womb to help her pregnancy. January 2008, Karen had her twin babies. This invention had aroused world wide attention.
The difference between "Eco-uterine" and the mechanization uterine was that the artificial of uterus material was made of human skin and the pure biological material and imitating a real and very close to the uterus of the birth environment. It avoided rejection when it was transplanted in the human body and it could become a real part of the human body after implantation. It cost low, promoted easy and the high rate of pregnancy. If it was promoted, it would bring more wish to women who injured or removed of the uterus. Webert Williams, 22-year-old, a real estate dealer in 1992. His wife, Karen, 24 years old, an ordinary staff which local social welfare and security of the Foundation. They wanted to have their own children, but Karen can’t be pregnancy. Unfortunately, Karen was diagnosed with early uterine cancer, and she had to have a hysterectomy surgery in Leeds City hospital, December 1999. Karen was very sad. She couldn’t cry when she saw young mothers which embracing baby. Wilbert became hot temper and indulging in alcohol. The Couple became indifferent to the feelings each other more and more. Karen tried to convince her husband to surrogate test-tube baby. The test-tube babies were not only a low success rate, but the price was very expensive. One day, July 2005, "Reproductive science" was on the Leeds public cable television network. Professor Christopher MacDermid, British fertility expert, London hospital Research Center, was invited to be a guest. At that time, he had a main research project "Ecological artificial uterus". Karen called Chris with the last glimmer hope. Professor Chris told Karen said that ecological research was still in the uterus, but he suggested that Karen could come to the hospital to check .if the physical conditions was permitting, she would may have her baby. In late July, the couple arrived in London with hope to see Professor Chris. Professor made a detailed physical examination for Chris. He found that both sides of ovarian function were very developed. They provided a prerequisite for the future of the uterus transplantation. Professor Christopher started to research the ecological uterus in early 2004. He had been engaged in reproductive research for a long time. He liked to talk with the pregnant women and asked them the feeling of pregnant. When he saw some women couldn’t have her baby which uterus removed or womb inherent weaknesses. He decided to find a new type of artificial womb, which could be implanted human body and became truly a part of the human body.
The uterus is women-specific organ; its function is controlling the influence of the hormone produced menstrual and breeding fetus. The Hysterectomy is less bad for the health of women. Vital organs don’t connect with it, so it's much smaller dangerous to transplant uterus. The most problem is in the body of the immune rejection. he wanted to find a suitable biological material to resolve the problem.
The most difficult hurdle in Organ Transplant was that the organ could not be immune rejection when it was transplanted into a human body. Professor Christopher got the best way to make the uterine after several experiments. The human bodies own cells and tissue could "create" some of the biological activity of the organ or tissue. Chris extracted a small amount of uterine tissue from the uterus wall of mice, then sterilized, digested, separated and cultured medium. When the quantity of cell was sufficient, he synthesized these organizations for the uterine wall. After repeated tests, he had found the best way to train the uterus wall.
He also cultured human uterus wall from the womb of cell which donated by volunteers. This structure and function of the uterus looked like the uterus of the real structure. It is divided into three tiers: the outer membrane uterine, endometrial and uterine muscle. Then, he filled some good elasticity thing into the real womb. He made a mold when it became the round one. The cultured cells could put in it in order to grow bigger which it could be in accordance with the mold.
In order to increase the flexibility of the uterus wall, he found “fibronectin” to control the uterus wall stretching freely. Endometrial had a physiological cycle by adjusting the temperature.
He began to experiment on animals. The mice had strong pain when Chris put the ecological uterus in its body. They became quiet when he finished suturing wounds in the end. the trial total of The mice was 10,Participate in of a of 10 rats, only one had fierce response, because it had mildly blood Cypriots. He had a success, despite the emergence of some small individual accidents.
Whether the fertilized egg could implantation on the endometrial or not was a key issue. The experiment in starting was not smooth. He found the reasons that inadequate nutrition and estrogen. Chris found a way to solve the problem. First, overlapped endometrial increasing thickness; second, injected estrogen in the body when it needed whenever.
The embryo became a fetus when it was provided enough progesterone and estrogen. Experiments showed that transplanting the ecological uterus in the body had 80 percent.
Professor Chris thought of Karen immediately. He didn’t know whether told the news to Karen or not. Eventually, he didn’t want Karen to have a adventure. Karen called Chris and told him that her husband would Divorce with her because she couldn’t bear the children. When Karen learned the succeeding experiments, she told Chris that she would be a true body, whether it was succeeding or not. Chris agreed. Sep.11, 2006, the first biological womb transplanting was beginning. Professor Chris started to experiment on Karen. Chris cut a small mouth in her abdomen and put ecological uterine in her body. Then he connected with the bilateral tubes, combined cervical of the uterus and the ligament organizations around the phase grounding. Ecological uterus was fixed between the bladder and rectum firmly. The ecological uterine couldn’t combined with other organs at first. In the end, it combined with others. Ecological uterus didn’t have a exclusion with other organizations in 20 hours inspecting. Karen felt hot and a little pain in the abdominal. The symptoms reduced a few days later. The wound between uterine and other organizations was healing. Uterine had not abnormal phenomenon. Karen was pleased to go home after a period of time. Half one month, Karen had the menstruation after she was transplanted uterus. She couldn’t help crying. The ovarian also had normal ovulation. She had a normal sex life as before. May 2007, Karen went to hospital for a routine inspection. Medical staff was surprised to find that she was pregnant for 50 days, even had double embryo implantation. Professor Chris also had an excitement. He saw the eco-uterine blood supplying adequate, appropriate thickness of the endometrium, moderate acidity, the normal double embryonic development. They proofed she could continue to be pregnancy. Karen and her husband were very happy. One day, Karen felt pain, and flowed out a small amount of blood. She was worried that she had an abortion. Chris checked for her and suggested her to have a rest more and had some medicine. Karen had a serious reaction, but she was also happy. She liked to talk with the babies. Karen felt very uncomfortable as the growing fetus. She could feel particularly tight on the womb. Chris said that if she felt serious discomfort, she would terminate pregnancy. She was worried. Later she felt so discomfort that she had to terminate pregnancy in 7 months pregnancy.
She had twin babies, Brother Nigel, 2.1 pounds, Sister Edith., 1.7 pounds. They are healthy. Karen said：“I think pregnancy is wonderful and well-being. Two children are the most precious gift that the God give us, they grow very healthy and lively, we love them. Thanks Professor Christopher the other health care workers. This is a real miracle. "
Professor Christopher told reporters on the achievements of the new technology: “ecological womb is from the human body, so their genes are very similar. Transplanting ecological artificial uterus in the body, it will not have a rejection, and the uterus could become one part of the real body later. the ecological uterine in the human body can not only direct link ovarian ovulation, format menstruation and conceive naturally, but also the pregnant mother could feel the happiness of mothers experience. But it is still at experimental stage. Like Karen, the great test to the flexibility of the uterine wall. We will continue to improve technology and benefit more women. "
George Brent, Reproductive Professor in University of Pennsylvania Centre, said: "The way of eco-uterine is completely eco-way, combination with natural human tissue and gestate fetus. The value of ecological uterus transplanting is more than the value of living transplantation. It is really a great achievement. It will solve the infertility and be benefit for the women who Uterine malformation or removal. If it is promoted extensively in the clinic, it will help a child and those parents. However, it is not fitting for any women; it is depending on the individual. "
