Kalirin

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kalirin, RhoGEF kinase
Identifiers
Symbol KALRN
Alt. Symbols HAPIP
Entrez 8997
HUGO 4814
OMIM 604605
RefSeq NM_003947
UniProt O60229
Other data
Locus Chr. 3 q21.2

Kalirin (other names: huntingtin-associated protein interacting protein, HAPIP; DUO) is a member of Dbl family of proteins and a Rho guanine nucleotide exchange factor. It is named after the multiple-handed Hindu goddess Kali for its ability to interact with numerous other proteins. Kalirin's other name, DUO, comes from the fact that it is 98% identical to rat DUO protein and 80.6% identical to a human protein named TRIO. Unlike TRIO, which is expressed in numerous tissues, Kalirin isoforms are mainly found in the brain. Kalirin was first identified in 1997 as a protein interacting with huntingtin-associated protein 1.[1]

Several isoforms of Kalirin are produced through alternative splicing.[2] One of the isoforms, Kalirin-7, was found to be necessary for the remodeling of synapses in mature cortical neurons.[3][4]

Biological Function of Kalirin

Kalirin is known to play an important role in nerve growth and axonal development.[5]


[edit] References

  1. ^ Colomer V, Engelender S, Sharp AH, Duan K, Cooper JK, Lanahan A, Lyford G, Worley P, Ross CA (1997). "Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain". Hum. Mol. Genet. 6 (9): 1519–25. PMID 9285789. 
  2. ^ McPherson CE, Eipper BA, Mains RE (2002). "Genomic organization and differential expression of Kalirin isoforms". Gene 284 (1-2): 41–51. PMID 11891045. 
  3. ^ Xie Z, Srivastava DP, Photowala H, Kai L, Cahill ME, Woolfrey KM, Shum CY, Surmeier DJ, Penzes P (2007). "Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines". Neuron 56 (4): 640–56. doi:10.1016/j.neuron.2007.10.005. PMID 18031682. 
  4. ^ Pat McCaffrey. Architect of Synaptic Plasticity Links Spine Form and Function - Schizophrenia Research Forum, 2007-11-30.
  5. ^ Molecular and Cellular Biology, June 2005, p. 5106-5118, Vol. 25, No. 12 0270-7306/05/$08.00+0 doi:10.1128/MCB.25.12.5106-5118.2005 Critical Role for Kalirin in Nerve Growth Factor Signaling through TrkA


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