Ka/Ks ratio

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In genetics, the K_a/K_s ratio or d_N/d_S ratio is the ratio of the rate of non-synonymous substitutions (K_a) to the rate of synonymous substitutions (K_s), which can be used as an indication of positive selection on a protein-coding gene. [1]

v • d • e Topics in molecular evolution Natural selection Background selection • Balancing selection • Directional selection • Disruptive selection • Negative selection • Stabilizing selection • Selective sweep Models Models of DNA evolution • Models of nucleotide substitution • Allele frequency • Ka/Ks ratio • Tajima's D Molecular processes Gene conversion • Gene duplication • Silent mutation • Synonymous substitution