Juvenile-hormone esterase

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In enzymology, a juvenile-hormone esterase (EC 3.1.1.59) is an enzyme that catalyzes the chemical reaction

methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H₂O $\rightleftharpoons$ (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol

The 3 substrates of this enzyme are methyl, (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate, and H₂O, whereas its two products are (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate and methanol.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-die noate acylhydrolase. Other names in common use include JH-esterase, juvenile hormone analog esterase, and juvenile hormone carboxyesterase.

[edit] References

IUBMB entry for 3.1.1.59
BRENDA references for 3.1.1.59 (Recommended.)
PubMed references for 3.1.1.59
PubMed Central references for 3.1.1.59
Google Scholar references for 3.1.1.59
Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM (2006). "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics. 6: 2726–32. doi:10.1002/pmic.200500419. PMID 16526094.
Mitsui T, Riddiford LM and Bellamy G (1979). "Metabolism of juvenile hormone by the epidermis of the tobacco hornworm (Manduca sexta)". Insect Biochem. 9: 637–643. doi:10.1016/0020-1790(79)90103-3.