JUP

From Wikipedia, the free encyclopedia

Junction plakoglobin

Identifiers

JUP; DP3; CTNNG; DPIII; PDGB; PKGB

External IDs

OMIM: 173325 MGI: 96650 HomoloGene: 1680

Gene ontology
Molecular Function:	• structural molecule activity • binding • cytoskeletal protein binding
Cellular Component:	• membrane fraction • soluble fraction • cytoplasm • cytosol • cytoskeleton • cell-cell adherens junction • desmosome
Biological Process:	• cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002230 (mRNA)
NP_002221 (protein)

NM_010593 (mRNA)
NP_034723 (protein)

Location

Chr 17: 37.16 - 37.2 Mb

Chr 11: 100.19 - 100.21 Mb

Pubmed search

[1]

[2]

Junction plakoglobin, also known as JUP, is a human gene.

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.^[1]

[edit] References

^ Entrez Gene: JUP junction plakoglobin.

[edit] Further reading

Beavon IR (2000). "The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.". Eur. J. Cancer 36 (13 Spec No): 1607–20. PMID 10959047.
Wilson PD (2001). "Polycystin: new aspects of structure, function, and regulation.". J. Am. Soc. Nephrol. 12 (4): 834–45. PMID 11274246.
Protonotarios NI, Tsatsopoulou AA, Gatzoulis KA (2002). "Arrhythmogenic right ventricular cardiomyopathy caused by a deletion in plakoglobin (Naxos disease).". Cardiac electrophysiology review 6 (1-2): 72–80. PMID 11984022.
Knudsen KA, Wheelock MJ (1992). "Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.". J. Cell Biol. 118 (3): 671–9. PMID 1639850.
Arnemann J, Spurr NK, Wheeler GN, et al. (1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).". Genomics 10 (3): 640–5. PMID 1889810.
Franke WW, Goldschmidt MD, Zimbelmann R, et al. (1989). "Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein.". Proc. Natl. Acad. Sci. U.S.A. 86 (11): 4027–31. PMID 2726765.
Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.". J. Cell Biol. 130 (2): 461–71. PMID 7542250.
Aberle H, Bierkamp C, Torchard D, et al. (1995). "The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers.". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6384–8. PMID 7604000.
Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR (1995). "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.". J. Biol. Chem. 270 (34): 20201–6. PMID 7650039.
Daniel JM, Reynolds AB (1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.". Mol. Cell. Biol. 15 (9): 4819–24. PMID 7651399.
Kanai Y, Ochiai A, Shibata T, et al. (1995). "c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.". Biochem. Biophys. Res. Commun. 208 (3): 1067–72. doi:10.1006/bbrc.1995.1443. PMID 7702605.
Roh JY, Stanley JR (1995). "Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment.". J. Invest. Dermatol. 104 (5): 720–4. PMID 7738346.
Shibamoto S, Hayakawa M, Takeuchi K, et al. (1995). "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.". J. Cell Biol. 128 (5): 949–57. PMID 7876318.
Rubinfeld B, Souza B, Albert I, et al. (1995). "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.". J. Biol. Chem. 270 (10): 5549–55. PMID 7890674.
Troyanovsky SM, Troyanovsky RB, Eshkind LG, et al. (1994). "Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 10790–4. PMID 7971964.
Shibata T, Gotoh M, Ochiai A, Hirohashi S (1994). "Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation.". Biochem. Biophys. Res. Commun. 203 (1): 519–22. doi:10.1006/bbrc.1994.2213. PMID 8074697.
Hinck L, Näthke IS, Papkoff J, Nelson WJ (1994). "Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.". J. Cell Biol. 125 (6): 1327–40. PMID 8207061.
Arnemann J, Sullivan KH, Magee AI, et al. (1993). "Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis.". J. Cell. Sci. 104 ( Pt 3): 741–50. PMID 8314871.
Ozawa M, Nuruki K, Toyoyama H, Ohi Y (1996). "Cloning of an alternative form of plakoglobin (gamma-catenin) lacking the fourth armadillo repeat.". J. Biochem. 118 (4): 836–40. PMID 8576101.
Fuchs M, Müller T, Lerch MM, Ullrich A (1996). "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family.". J. Biol. Chem. 271 (28): 16712–9. PMID 8663237.