User:JonSDSUGrad/Sandbox/TestA REC8

From Wikipedia, the free encyclopedia

REC8-like 1 (yeast)

Identifiers

REC8L1; HR21spB; MGC950; REC8; Rec8p

External IDs

OMIM: 608193 MGI: 1929645 HomoloGene: 3768

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nuclear chromosome • lateral element • nucleus
Biological Process:	• sister chromatid cohesion • meiosis • meiotic recombination • spermatogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001048205 (mRNA)
NP_001041670 (protein)

NM_020002 (mRNA)
NP_064386 (protein)

Location

Chr 14: 23.71 - 23.72 Mb

Chr 14: 54.57 - 54.58 Mb

Pubmed search

[1]

[2]

REC8-like 1 (yeast), also known as REC8L1, is a human gene.^[1]

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: REC8L1 REC8-like 1 (yeast).

[edit] Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Xu H, Beasley MD, Warren WD, et al. (2005). "Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis.". Dev. Cell 8 (6): 949-61. doi:10.1016/j.devcel.2005.03.018. PMID 15935783.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Prieto I, Tease C, Pezzi N, et al. (2004). "Cohesin component dynamics during meiotic prophase I in mammalian oocytes.". Chromosome Res. 12 (3): 197-213. PMID 15125634.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Lee J, Iwai T, Yokota T, Yamashita M (2004). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis.". J. Cell. Sci. 116 (Pt 13): 2781-90. doi:10.1242/jcs.00495. PMID 12759374.
Schleiffer A, Kaitna S, Maurer-Stroh S, et al. (2003). "Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.". Mol. Cell 11 (3): 571-5. PMID 12667442.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Parisi S, McKay MJ, Molnar M, et al. (1999). "Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans.". Mol. Cell. Biol. 19 (5): 3515-28. PMID 10207075.