User:JonSDSUGrad/Sandbox/TestA RCE1

From Wikipedia, the free encyclopedia

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

Identifiers

RCE1; FACE2; RCE1A; RCE1B

External IDs

OMIM: 605385 MGI: 1336895 HomoloGene: 3769

Gene ontology
Molecular Function:	• prenyl-dependent CAAX protease activity • hydrolase activity
Cellular Component:	• endoplasmic reticulum • integral to plasma membrane • membrane
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001129665 (mRNA)
XP_001129665 (protein)

NM_023131 (mRNA)
NP_075620 (protein)

Location

Chr 11: 66.37 - 66.37 Mb

Chr 19: 4.62 - 4.63 Mb

Pubmed search

[1]

[2]

RCE1 homolog, prenyl protein peptidase (S. cerevisiae), also known as RCE1, is a human gene.^[1]

This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: RCE1 RCE1 homolog, prenyl protein peptidase (S. cerevisiae).

[edit] Further reading

Plummer LJ, Hildebrandt ER, Porter SB, et al. (2006). "Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.". J. Biol. Chem. 281 (8): 4596-605. doi:10.1074/jbc.M506284200. PMID 16361710.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Bergo MO, Lieu HD, Gavino BJ, et al. (2004). "On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.". J. Biol. Chem. 279 (6): 4729-36. doi:10.1074/jbc.M310081200. PMID 14625273.
Maske CP, Hollinshead MS, Higbee NC, et al. (2003). "A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation.". J. Cell Biol. 162 (7): 1223-32. doi:10.1083/jcb.200303113. PMID 14504265.
Hollander IJ, Frommer E, Aulabaugh A, Mallon R (2003). "Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides.". Biochim. Biophys. Acta 1649 (1): 24-9. PMID 12818187.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hollander I, Frommer E, Mallon R (2000). "Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides.". Anal. Biochem. 286 (1): 129-37. doi:10.1006/abio.2000.4795. PMID 11038283.
Freije JM, Blay P, Pendás AM, et al. (1999). "Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins.". Genomics 58 (3): 270-80. doi:10.1006/geno.1999.5834. PMID 10373325.
Otto JC, Kim E, Young SG, Casey PJ (1999). "Cloning and characterization of a mammalian prenyl protein-specific protease.". J. Biol. Chem. 274 (13): 8379-82. PMID 10085068.