User:JonSDSUGrad/Sandbox/TEST NFKB1
From Wikipedia, the free encyclopedia
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nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
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| Identifiers | ||
| Symbol(s) | NFKB1; DKFZp686C01211; EBP-1; KBF1; MGC54151; NF-kappa-B; NFKB-p105; NFKB-p50 | |
| External IDs | OMIM: 164011 MGI: 97312 HomoloGene: 2971 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 4790 | 18033 |
| Ensembl | ENSG00000109320 | ENSMUSG00000028163 |
| Uniprot | P19838 | P25799 |
| Refseq | NM_003998 (mRNA) NP_003989 (protein) |
NM_008689 (mRNA) NP_032715 (protein) |
| Location | Chr 4: 103.64 - 103.76 Mb | Chr 3: 135.29 - 135.61 Mb |
| Pubmed search | [1] | [2] |
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.
