User:JonSDSUGrad/Sandbox/TEST MAPK1

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mitogen-activated protein kinase 1
Identifiers
Symbol(s)	MAPK1; p38; ERK; p40; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p41; p41mapk
External IDs	OMIM: 176948 MGI: 1346858 HomoloGene: 37670
Gene ontology Molecular Function: • MAPKKK cascade • nucleotide binding • phosphotyrosine binding • protein serine/threonine kinase activity • MAP kinase activity • protein binding • ATP binding • nucleus • cytoplasm • protein amino acid phosphorylation • induction of apoptosis • chemotaxis • response to DNA damage stimulus • cell cycle • signal transduction • synaptic transmission • organ morphogenesis • transferase activity • cytosine metabolic process
Orthologs
	Human	Mouse
Entrez	5594	26413
Ensembl	ENSG00000100030	ENSMUSG00000063358
Uniprot	P28482	P63085
Refseq	NM_002745 (mRNA) NP_002736 (protein)	NM_001038663 (mRNA) NP_001033752 (protein)
Location	Chr 22: 20.45 - 20.55 Mb	Chr 16: 16.9 - 16.96 Mb
Pubmed search	[1]	[2]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.