User:JonSDSUGrad/Sandbox/TEST IGF1

From Wikipedia, the free encyclopedia

insulin-like growth factor 1 (somatomedin C)
Identifiers
Symbol(s)	IGF1; IGFI
External IDs	OMIM: 147440 MGI: 96432 HomoloGene: 515
Gene ontology Molecular Function: • skeletal development • insulin-like growth factor receptor binding • hormone activity • protein binding • extracellular region • extracellular space • DNA replication • anti-apoptosis • cell motility • signal transduction • Ras protein signal transduction • nervous system development • muscle development • sensory perception of sound • growth factor activity • positive regulation of cell proliferation • glycolate metabolic process • organ morphogenesis • glial cell differentiation • prothoracicotrophic hormone activity • insulin-like growth factor receptor signaling pathway • cell development
Orthologs
	Human	Mouse
Entrez	3479	16000
Ensembl	ENSG00000017427	ENSMUSG00000020053
Uniprot	P05019	P05017
Refseq	NM_000618 (mRNA) NP_000609 (protein)	NM_010512 (mRNA) NP_034642 (protein)
Location	Chr 12: 101.31 - 101.4 Mb	Chr 10: 87.29 - 87.36 Mb
Pubmed search	[1]	[2]

The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003).[supplied by OMIM]