User:JonSDSUGrad/Sandbox/TEST8 Bcl-2

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B-cell CLL/lymphoma 2
PDB rendering based on 2o2f.
Available structures: 2o2f
Identifiers
Symbol(s) BCL2; Bcl-2
External IDs OMIM: 151430 MGI: 88138 HomoloGene: 527
Orthologs
Human Mouse
Entrez 596 12043
Ensembl ENSG00000171791 ENSMUSG00000057329
Uniprot P10415 n/a
Refseq NM_000633 (mRNA)
NP_000624 (protein)		 NM_009741 (mRNA)
NP_033871 (protein)
Location Chr 18: 58.94 - 59.14 Mb Chr 1: 108.37 - 108.54 Mb
Pubmed search [1] [2]

[edit] Summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.[1]

[edit] References

  1. ^ Entrez Gene: BCL2 B-cell CLL/lymphoma 2. Retrieved on 2007-08-10.

[edit] Further reading

  • Reed JC, Zha H, Aime-Sempe C, et al. (1997). "Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death.". Adv. Exp. Med. Biol. 406: 99-112. PMID 8910675. 
  • Zauli G, Gibellini D (1997). "The human immunodeficiency virus type-1 (HIV-1) Tat protein and Bcl-2 gene expression.". Leuk. Lymphoma 23 (5-6): 551-60. PMID 9031086. 
  • Deng X, Kornblau SM, Ruvolo PP, May WS (2003). "Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance.". J. Natl. Cancer Inst. Monographs (28): 30-7. PMID 11158204. 
  • Vieira HL, Haouzi D, El Hamel C, et al. (2001). "Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator.". Cell Death Differ. 7 (12): 1146-54. doi:10.1038/sj.cdd.4400778. PMID 11175251. 
  • Ruvolo PP, Deng X, May WS (2001). "Phosphorylation of Bcl2 and regulation of apoptosis.". Leukemia 15 (4): 515-22. PMID 11368354. 
  • Marone M, Bonanno G, Rutella S, et al. (2003). "Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21.". Leuk. Lymphoma 43 (1): 51-7. PMID 11908736. 
  • Irvine AE, McMullin MF, Ong YL (2002). "Bcl-2 family members as prognostic indicators in AML.". Hematology 7 (1): 21-31. doi:10.1080/10245330290011838. PMID 12171774. 
  • Cory S, Adams JM (2002). "The Bcl2 family: regulators of the cellular life-or-death switch.". Nat. Rev. Cancer 2 (9): 647-56. doi:10.1038/nrc883. PMID 12209154. 
  • Catz SD, Johnson JL (2003). "BCL-2 in prostate cancer: a minireview.". Apoptosis 8 (1): 29-37. PMID 12510149. 
  • Ouyang YB, Giffard RG (2005). "Cellular neuroprotective mechanisms in cerebral ischemia: Bcl-2 family proteins and protection of mitochondrial function.". Cell Calcium 36 (3-4): 303-11. doi:10.1016/j.ceca.2004.02.015. PMID 15261486. 
  • Seelamgari A, Maddukuri A, Berro R, et al. (2006). "Role of viral regulatory and accessory proteins in HIV-1 replication.". Front. Biosci. 9: 2388-413. PMID 15353294. 
  • Hadar T, Shvero J, Yaniv E, et al. (2005). "Expression of p53, Ki-67 and Bcl-2 in parathyroid adenoma and residual normal tissue.". Pathol. Oncol. Res. 11 (1): 45-9. doi:PAOR.2005.11.1.0045. PMID 15800682. 
  • Muthumani K, Choo AY, Premkumar A, et al. (2006). "Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism.". Cell Death Differ. 12 Suppl 1: 962-70. doi:10.1038/sj.cdd.4401583. PMID 15832179. 
  • Soane L, Fiskum G (2006). "Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins.". J. Bioenerg. Biomembr. 37 (3): 179-90. doi:10.1007/s10863-005-6590-8. PMID 16167175.