User:JonSDSUGrad/Sandbox/TEST7 Bcl-2

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B-cell CLL/lymphoma 2
PDB rendering based on 2o2f.
Available structures: 2o2f
Identifiers
Symbol(s) BCL2; Bcl-2
External IDs OMIM: 151430 MGI: 88138 HomoloGene: 527
Orthologs
Human Mouse
Entrez 596 12043
Ensembl ENSG00000171791 ENSMUSG00000057329
Uniprot P10415 n/a
Refseq NM_000633 (mRNA)
NP_000624 (protein)		 NM_009741 (mRNA)
NP_033871 (protein)
Location Chr 18: 58.94 - 59.14 Mb Chr 1: 108.37 - 108.54 Mb
Pubmed search [1] [2]

[edit] Summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.[1]

[edit] References

  1. ^ Entrez Gene: BCL2 B-cell CLL/lymphoma 2. Retrieved on 2007-08-07.

[edit] Further reading

  • Reed JC, Zha H, Aime-Sempe C, Takayama S, Wang HG (1997). "Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death.". Advances in experimental medicine and biology 406: 99-112. PMID 8910675. 
  • Zauli G, Gibellini D (1997). "The human immunodeficiency virus type-1 (HIV-1) Tat protein and Bcl-2 gene expression.". Leukemia & lymphoma 23 (5-6): 551-60. PMID 9031086. 
  • Deng X, Kornblau SM, Ruvolo PP, May WS (2003). "Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance.". Journal of the National Cancer Institute. Monographs (28): 30-7. PMID 11158204. 
  • Vieira HL, Haouzi D, El Hamel C, Jacotot E, Belzacq AS, Brenner C, Kroemer G (2001). "Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator.". Cell death and differentiation 7 (12): 1146-54. doi:10.1038/sj.cdd.4400778. PMID 11175251. 
  • Ruvolo PP, Deng X, May WS (2001). "Phosphorylation of Bcl2 and regulation of apoptosis.". Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 15 (4): 515-22. PMID 11368354. 
  • Marone M, Bonanno G, Rutella S, Leone G, Scambia G, Pierelli L (2003). "Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21.". Leukemia & lymphoma 43 (1): 51-7. PMID 11908736. 
  • Irvine AE, McMullin MF, Ong YL (2002). "Bcl-2 family members as prognostic indicators in AML.". Hematology (Amsterdam, Netherlands) 7 (1): 21-31. doi:10.1080/10245330290011838. PMID 12171774. 
  • Cory S, Adams JM (2002). "The Bcl2 family: regulators of the cellular life-or-death switch.". Nature reviews. Cancer 2 (9): 647-56. doi:10.1038/nrc883. PMID 12209154. 
  • Catz SD, Johnson JL (2003). "BCL-2 in prostate cancer: a minireview.". Apoptosis : an international journal on programmed cell death 8 (1): 29-37. PMID 12510149. 
  • Ouyang YB, Giffard RG (2005). "Cellular neuroprotective mechanisms in cerebral ischemia: Bcl-2 family proteins and protection of mitochondrial function.". Cell calcium 36 (3-4): 303-11. doi:10.1016/j.ceca.2004.02.015. PMID 15261486. 
  • Seelamgari A, Maddukuri A, Berro R, de la Fuente C, Kehn K, Deng L, Dadgar S, Bottazzi ME, Ghedin E, Pumfery A, Kashanchi F (2006). "Role of viral regulatory and accessory proteins in HIV-1 replication.". Frontiers in bioscience : a journal and virtual library 9: 2388-413. PMID 15353294. 
  • Hadar T, Shvero J, Yaniv E, Ram E, Shvili I, Koren R (2005). "Expression of p53, Ki-67 and Bcl-2 in parathyroid adenoma and residual normal tissue.". Pathology oncology research : POR 11 (1): 45-9. doi:PAOR.2005.11.1.0045. PMID 15800682. 
  • Muthumani K, Choo AY, Premkumar A, Hwang DS, Thieu KP, Desai BM, Weiner DB (2006). "Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism.". Cell death and differentiation 12 Suppl 1: 962-70. doi:10.1038/sj.cdd.4401583. PMID 15832179. 
  • Soane L, Fiskum G (2006). "Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins.". Journal of bioenergetics and biomembranes 37 (3): 179-90. doi:10.1007/s10863-005-6590-8. PMID 16167175.