User:JonSDSUGrad/Sandbox/TEST6 TP53

From Wikipedia, the free encyclopedia

tumor protein p53 (Li-Fraumeni syndrome)

PDB rendering based on 1a1u.

Available structures: 1a1u, 1aie, 1c26, 1gzh, 1hs5, 1kzy, 1olg, 1olh, 1pes, 1pet, 1sae, 1saf, 1sag, 1sah, 1sai, 1saj, 1sak, 1sal, 1tsr, 1tup, 1uol, 1ycs, 2ac0, 2ady, 2ahi, 2ata, 2b3g, 2bim, 2bin, 2bio, 2bip, 2biq, 2fej, 2gs0, 2h1l, 2j1w, 2j1x, 2j1y, 2j1z, 2j20, 2j21, 2ocj, 3sak

Identifiers

Symbol(s)

TP53; LFS1; TRP53; p53

External IDs

OMIM: 191170 MGI: 98834 HomoloGene: 460

Gene ontology
Molecular Function:	• protein import into nucleus, translocation • DNA strand annealing activity • in utero embryonic development • transcription factor activity • nuclease activity • copper ion binding • protein binding • ATP binding • insoluble fraction • nucleus • nucleoplasm • replication fork • nucleolus • cytoplasm • mitochondrion • cytosol • base-excision repair • nucleotide-excision repair • transcription • regulation of transcription, DNA-dependent • protein complex assembly • apoptosis • induction of apoptosis • response to DNA damage stimulus • cell cycle • cell cycle arrest • multicellular organismal development • cell aging • protein localization • negative regulation of DNA replication • zinc ion binding • caspase activation via cytochrome c • response to UV • embryonic development ending in birth or egg hatching • response to X-ray • nuclear matrix • enzyme binding • cell differentiation • negative regulation of cell growth • G1 DNA damage checkpoint • regulation of cell proliferation • DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis • negative regulation of apoptosis • positive regulation of transcription • positive regulation of transcription from RNA polymerase II promoter • metal ion binding • regulation of mitochondrial membrane permeability • protein heterodimerization activity • protein N-terminus binding • negative regulation of fibroblast proliferation • negative regulation of helicase activity • protein tetramerization

Orthologs

Human

Mouse

n/a

Refseq

NM_000546 (mRNA)
NP_000537 (protein)

NM_011640 (mRNA)
NP_035770 (protein)

Location

Chr 17: 7.51 - 7.53 Mb

Chr 11: 69.4 - 69.41 Mb

Pubmed search

[1]

[2]

[edit] Summary

Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.^[1]