User:JonSDSUGrad/Sandbox/TEST6 PTGS2

From Wikipedia, the free encyclopedia

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Identifiers

PTGS2; COX2; PGG/HS; COX-2; PGHS-2; PHS-2; hCox-2

External IDs

OMIM: 600262 MGI: 97798 HomoloGene: 31000

Gene ontology
Molecular Function:	• prostaglandin biosynthetic process • peroxidase activity • prostaglandin-endoperoxide synthase activity • iron ion binding • nucleus • cytoplasm • fatty acid biosynthetic process • cell motility • blood pressure regulation • membrane • oxidoreductase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • cyclooxygenase pathway • keratinocyte differentiation • anagen • metal ion binding • regulation of inflammatory response

Orthologs

Human

Mouse

n/a

Refseq

NM_000963 (mRNA)
NP_000954 (protein)

NM_011198 (mRNA)
NP_035328 (protein)

Location

Chr 1: 184.91 - 184.92 Mb

Chr 1: 151.86 - 151.87 Mb

Pubmed search

[1]

[2]

[edit] Summary

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS2, which shows 86% - 89% amino acid sequence identity with mouse, rat, sheep, bovine, horse and rabit PTGS2 proteins, respectively. Human PTGS2 is expressed in a limited number of cell types and regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. The expression of this gene is deregulated in epithelial tumors.^[1]