User:JonSDSUGrad/Sandbox/TEST6 PKC-alpha

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protein kinase C, alpha

PDB rendering based on 1dsy.

Available structures: 1dsy

Identifiers

Symbol(s)

PRKCA; PRKACA; AAG6; MGC129900; MGC129901; PKC-alpha; PKCA

External IDs

OMIM: 176960 MGI: 97595 HomoloGene: 55679

Gene ontology
Molecular Function:	• regulation of progression through cell cycle • nucleotide binding • inactivation of MAPK activity • negative regulation of protein amino acid phosphorylation • positive regulation of protein amino acid phosphorylation • cardiac inotropy • calcium-dependent protein kinase C activity • calcium ion binding • protein binding • ATP binding • membrane fraction • nucleus • cytoplasm • mitochondrion • protein amino acid phosphorylation • negative regulation of protein kinase activity • cellular calcium ion homeostasis • regulation of muscle contraction • cell surface receptor linked signal transduction • intracellular signaling cascade • zinc ion binding • induction of apoptosis by extracellular signals • induction of apoptosis by intracellular signals • transferase activity • diacylglycerol binding • neutrophil chemotaxis • negative regulation of glucose import • negative regulation of insulin receptor signaling pathway • positive regulation of inflammatory response • regulation of peptidyl-tyrosine phosphorylation • induction of positive chemotaxis

Orthologs

Human

Mouse

n/a

Refseq

NM_002737 (mRNA)
NP_002728 (protein)

NM_011101 (mRNA)
NP_035231 (protein)

Location

Chr 17: 61.73 - 62.24 Mb

Chr 11: 107.75 - 108.16 Mb

Pubmed search

[1]

[2]

[edit] Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.^[1]