User:JonSDSUGrad/Sandbox/TEST6 MMP9

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matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

PDB rendering based on 1itv.

Available structures: 1itv, 1l6j

Identifiers

Symbol(s)

MMP9; CLG4B; GELB; MMP-9

External IDs

OMIM: 120361 MGI: 97011 HomoloGene: 3659

Gene ontology
Molecular Function:	• peptidoglycan metabolic process • skeletal development • gelatinase B activity • calcium ion binding • collagen binding • proteinaceous extracellular matrix • extracellular space • proteolysis • collagenase activity • zinc ion binding • extracellular matrix organization and biogenesis • macrophage differentiation • collagen catabolic process • positive regulation of apoptosis

Orthologs

Human

Mouse

n/a

Refseq

NM_004994 (mRNA)
NP_004985 (protein)

NM_013599 (mRNA)
NP_038627 (protein)

Location

Chr 20: 44.07 - 44.08 Mb

Chr 2: 164.64 - 164.65 Mb

Pubmed search

[1]

[2]

[edit] Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.^[1]