User:JonSDSUGrad/Sandbox/TEST6 Interleukin 8

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interleukin 8

PDB rendering based on 1icw.

Available structures: 1icw, 1ikl, 1ikm, 1il8, 1ilp, 1ilq, 1qe6, 2il8, 3il8

Identifiers

Symbol(s)

IL8; 3-10C; AMCF-I; CXCL8; GCP-1; GCP1; K60; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; SCYB8; TSG-1; b-ENAP

External IDs

OMIM: 146930 HomoloGene: 47937

Gene ontology
Molecular Function:	• angiogenesis • interleukin-8 receptor binding • protein binding • extracellular region • extracellular space • cell motility • chemotaxis • inflammatory response • immune response • cell cycle arrest • G-protein coupled receptor protein signaling pathway • intracellular signaling cascade • cell-cell signaling • chemokine activity • negative regulation of cell proliferation • calcium-mediated signaling • regulation of cell adhesion • neutrophil chemotaxis • neutrophil activation • regulation of retroviral genome replication • induction of positive chemotaxis

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_000584 (mRNA)
NP_000575 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 4: 74.83 - 74.83 Mb

n/a

Pubmed search

[1]

n/a

[edit] Summary

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.^[1]