User:JonSDSUGrad/Sandbox/TEST6 Insulin-like growth factor 1

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insulin-like growth factor 1 (somatomedin C)

PDB rendering based on 1bqt.

Available structures: 1bqt, 1gzr, 1gzy, 1gzz, 1h02, 1h59, 1imx, 1pmx, 1wqj, 2dsp, 2dsq, 2dsr, 2gf1, 3gf1, 3lri

Identifiers

Symbol(s)

IGF1; IGFI

External IDs

OMIM: 147440 MGI: 96432 HomoloGene: 515

Gene ontology
Molecular Function:	• skeletal development • insulin-like growth factor receptor binding • hormone activity • protein binding • extracellular region • extracellular space • DNA replication • anti-apoptosis • cell motility • signal transduction • Ras protein signal transduction • nervous system development • muscle development • sensory perception of sound • growth factor activity • positive regulation of cell proliferation • glycolate metabolic process • organ morphogenesis • glial cell differentiation • prothoracicotrophic hormone activity • insulin-like growth factor receptor signaling pathway • cell development

Orthologs

Human

Mouse

n/a

Refseq

NM_000618 (mRNA)
NP_000609 (protein)

NM_010512 (mRNA)
NP_034642 (protein)

Location

Chr 12: 101.31 - 101.4 Mb

Chr 10: 87.29 - 87.36 Mb

Pubmed search

[1]

[2]

[edit] Summary

The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003).[supplied by OMIM]^[1]