User:JonSDSUGrad/Sandbox/TEST6 HLA-B

From Wikipedia, the free encyclopedia

major histocompatibility complex, class I, B

PDB rendering based on 1a1n.

Available structures: 1a1n, 1a9b, 1a9e, 1agb, 1agc, 1agd, 1age, 1agf, 1cg9, 1e27, 1e28, 1efx, 1hsa, 1jgd, 1jge, 1k5n, 1m05, 1mi5, 1of2, 1ogt, 1uxs, 1uxw, 1w0v, 1w0w, 1xh3, 1xr8, 1xr9, 1zhk, 1zhl, 1zsd, 2a83, 2ak4, 2axf, 2axg, 2bsr, 2bss, 2bst, 2cik, 2fyy, 2fz3, 2h6p, 2nw3, 2nx5

Identifiers

Symbol(s)

HLA-B; HLA B; SPDA1

External IDs

OMIM: 142830 HomoloGene: 83181

Gene ontology
Molecular Function:	• antigen processing and presentation of peptide antigen via MHC class I • molecular_function • cellular_component • membrane fraction • integral to plasma membrane • defense response • immune response • biological_process • membrane • integral to membrane • antigen processing and presentation • MHC class I receptor activity • MHC class I protein complex

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_005514 (mRNA)
NP_005505 (protein)

NM_001025208 (mRNA)
NP_001020379 (protein)

Location

Chr 6: 31.43 - 31.43 Mb

n/a

Pubmed search

[1]

[2]

[edit] Summary

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described^[1]