User:JonSDSUGrad/Sandbox/TEST6 HER2

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v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

PDB rendering based on 1n8z.

Available structures: 1n8z, 1s78, 2a91

Identifiers

Symbol(s)

ERBB2; HER-2; HER-2/neu; HER2; NEU; NGL; TKR1; c-erb B2

External IDs

OMIM: 164870 MGI: 95410 HomoloGene: 3273

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • receptor activity • epidermal growth factor receptor activity • iron ion binding • ATP binding • extracellular region • cytoplasm • plasma membrane • electron transport • protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • peripheral nervous system development • heart development • cell proliferation • electron carrier activity • membrane • integral to membrane • apical plasma membrane • transferase activity • mammary gland development • myelination • identical protein binding • ErbB-3 class receptor binding • positive regulation of MAPK activity • regulation of angiogenesis • protein heterodimerization activity • phosphoinositide-mediated signaling • positive regulation of epithelial cell proliferation

Orthologs

Human

Mouse

n/a

Refseq

NM_004448 (mRNA)
NP_004439 (protein)

NM_001003817 (mRNA)
NP_001003817 (protein)

Location

Chr 17: 35.1 - 35.14 Mb

Chr 11: 98.23 - 98.25 Mb

Pubmed search

[1]

[2]

[edit] Summary

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.^[1]