User:JonSDSUGrad/Sandbox/TEST6 CD29

From Wikipedia, the free encyclopedia

integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

Identifiers

ITGB1; CD29; FNRB; GPIIA; MDF2; MSK12; VLAB

External IDs

OMIM: 135630 MGI: 96610 HomoloGene: 22999

Gene ontology
Molecular Function:	• ruffle • receptor activity • protein binding • endoplasmic reticulum • cellular defense response • cell adhesion • homophilic cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • multicellular organismal development • integrin complex • membrane • integral to membrane • cell migration • identical protein binding • protein heterodimerization activity

Orthologs

Human

Mouse

n/a

Refseq

NM_033668 (mRNA)
NP_391988 (protein)

NM_010578 (mRNA)
NP_034708 (protein)

Location

Chr 10: 33.23 - 33.29 Mb

Chr 8: 131.59 - 131.62 Mb

Pubmed search

[1]

[2]

[edit] Summary

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.^[1]