User:JonSDSUGrad/Sandbox/TEST6 Bcl-2

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B-cell CLL/lymphoma 2
PDB rendering based on 2o2f.
Available structures: 2o2f
Identifiers
Symbol(s)	BCL2; Bcl-2
External IDs	OMIM: 151430 MGI: 88138 HomoloGene: 527
Gene ontology Molecular Function: • regulation of progression through cell cycle • release of cytochrome c from mitochondria • nucleus • mitochondrion • mitochondrial outer membrane • endoplasmic reticulum • cytosol • anti-apoptosis • humoral immune response • membrane • integral to membrane • identical protein binding • regulation of cellular pH • negative regulation of mitochondrial depolarization
Orthologs
	Human	Mouse
Entrez	596	12043
Ensembl	ENSG00000171791	ENSMUSG00000057329
Uniprot	P10415	n/a
Refseq	NM_000633 (mRNA) NP_000624 (protein)	NM_009741 (mRNA) NP_033871 (protein)
Location	Chr 18: 58.94 - 59.14 Mb	Chr 1: 108.37 - 108.54 Mb
Pubmed search	[1]	[2]

[edit] Summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.^[1]

[edit] References

1. ^ Entrez Gene: BCL2 B-cell CLL/lymphoma 2. Retrieved on 2007-08-07.

[edit] Further Reading