User:JonSDSUGrad/Sandbox/TEST5 TGFB1

From Wikipedia, the free encyclopedia

transforming growth factor
PDB rendering based on 1kla.
Available structures: 1kla, 1klc, 1kld
Identifiers
Symbol(s)	TGFB1; CED; DPD1; TGFB
External IDs	OMIM: 190180 MGI: 98725 HomoloGene: 540
Gene ontology Molecular Function: • skeletal development • transforming growth factor beta receptor binding • protein binding • proteinaceous extracellular matrix • extracellular space • protein amino acid phosphorylation • inflammatory response • transforming growth factor beta receptor signaling pathway • growth factor activity • cell death • positive regulation of cell proliferation • negative regulation of cell proliferation • germ cell migration • organ morphogenesis • cell growth • regulation of striated muscle development • negative regulation of transcription • transcription activator activity • negative regulation of ossification • regulation of protein import into nucleus • negative regulation of progression through cell cycle • positive regulation of transcription, DNA-dependent • positive regulation of isotype switching to IgA isotypes • lymph node development • regulation of DNA binding
Orthologs
	Human	Mouse
Entrez	7040	21803
Ensembl	ENSG00000105329	ENSMUSG00000002603
Uniprot	P01137	n/a
Refseq	NM_000660 (mRNA) NP_000651 (protein)	NM_011577 (mRNA) NP_035707 (protein)
Location	Chr 19: 46.53 - 46.55 Mb	Chr 7: 25.4 - 25.41 Mb
Pubmed search	[1]	[2]

[edit] Summary

TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM]