User:JonSDSUGrad/Sandbox/TEST5 SRC

From Wikipedia, the free encyclopedia

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
PDB rendering based on 1a07.
Available structures: 1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e, 1bkl, 1bkm, 1f1w, 1f2f, 1fmk, 1hcs, 1hct, 1is0, 1kc2, 1ksw, 1nlo, 1nlp, 1nzl, 1nzv, 1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4c, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4i, 1o4j, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r, 1p13, 1prl, 1prm, 1qwe, 1qwf, 1rlp, 1rlq, 1sha, 1shb, 1shd, 1skj, 1spr, 1sps, 1srl, 1srm, 1y57, 1yi6, 1yoj, 1yol, 1yom, 2bdf, 2bdj, 2h8h, 2hwo, 2hwp, 2oiq, 2ptk, 2src
Identifiers
Symbol(s)	SRC; ASV; SRC1; c-SRC; p60-Src
External IDs	OMIM: 190090 MGI: 98397 HomoloGene: 21120
Gene ontology Molecular Function: • nucleotide binding • protein-tyrosine kinase activity • SH3/SH2 adaptor activity • protein binding • ATP binding • protein amino acid phosphorylation • signal complex assembly • protein kinase cascade • membrane • integral to membrane • transferase activity • SH2 domain binding
Orthologs
	Human	Mouse
Entrez	6714	20779
Ensembl	ENSG00000197122	ENSMUSG00000027646
Uniprot	P12931	n/a
Refseq	NM_005417 (mRNA) NP_005408 (protein)	NM_001025395 (mRNA) NP_001020566 (protein)
Location	Chr 20: 35.41 - 35.47 Mb	Chr 2: 157.12 - 157.16 Mb
Pubmed search	[1]	[2]

[edit] Summary

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.