User:JonSDSUGrad/Sandbox/TEST5 NFKB1

From Wikipedia, the free encyclopedia

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
PDB rendering based on 1bfs.
Available structures: 1bfs, 1ikn, 1le5, 1le9, 1lei, 1nfi, 1nfk, 1ooa, 1svc, 1u36, 1u3j, 1u3y, 1u3z, 1u41, 1u42, 1vkx, 2dbf, 2i9t
Identifiers
Symbol(s)	NFKB1; DKFZp686C01211; EBP-1; KBF1; MGC54151; NF-kappa-B; NFKB-p105; NFKB-p50
External IDs	OMIM: 164011 MGI: 97312 HomoloGene: 2971
Gene ontology Molecular Function: • transcription factor activity • protein binding • nucleus • cytoplasm • transcription from RNA polymerase II promoter • apoptosis • anti-apoptosis • inflammatory response • signal transduction • specific transcriptional repressor activity • antibacterial humoral response • negative regulation of interleukin-12 biosynthetic process • negative regulation of transcription, DNA-dependent • positive regulation of transcription
Orthologs
	Human	Mouse
Entrez	4790	18033
Ensembl	ENSG00000109320	ENSMUSG00000028163
Uniprot	P19838	n/a
Refseq	NM_003998 (mRNA) NP_003989 (protein)	NM_008689 (mRNA) NP_032715 (protein)
Location	Chr 4: 103.64 - 103.76 Mb	Chr 3: 135.29 - 135.61 Mb
Pubmed search	[1]	[2]

[edit] Summary

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.