User:JonSDSUGrad/Sandbox/TEST5 MMP9

From Wikipedia, the free encyclopedia

matrix metallopeptidase 9 (gelatinase B
PDB rendering based on 1itv.
Available structures: 1itv, 1l6j
Identifiers
Symbol(s)	MMP9; CLG4B; GELB; MMP-9
External IDs	OMIM: 120361 MGI: 97011 HomoloGene: 3659
Gene ontology Molecular Function: • peptidoglycan metabolic process • skeletal development • gelatinase B activity • calcium ion binding • collagen binding • proteinaceous extracellular matrix • extracellular space • proteolysis • collagenase activity • zinc ion binding • extracellular matrix organization and biogenesis • macrophage differentiation • collagen catabolic process • positive regulation of apoptosis
Orthologs
	Human	Mouse
Entrez	4318	17395
Ensembl	ENSG00000100985	ENSMUSG00000017737
Uniprot	P14780	n/a
Refseq	NM_004994 (mRNA) NP_004985 (protein)	NM_013599 (mRNA) NP_038627 (protein)
Location	Chr 20: 44.07 - 44.08 Mb	Chr 2: 164.64 - 164.65 Mb
Pubmed search	[1]	[2]

[edit] Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.