User:JonSDSUGrad/Sandbox/TEST5 ITGB1

From Wikipedia, the free encyclopedia

integrin
Identifiers
Symbol(s)	ITGB1; CD29; FNRB; GPIIA; MDF2; MSK12; VLAB
External IDs	OMIM: 135630 MGI: 96610 HomoloGene: 22999
Gene ontology Molecular Function: • ruffle • receptor activity • protein binding • endoplasmic reticulum • cellular defense response • cell adhesion • homophilic cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • multicellular organismal development • integrin complex • membrane • integral to membrane • cell migration • identical protein binding • protein heterodimerization activity
Orthologs
	Human	Mouse
Entrez	3688	16412
Ensembl	ENSG00000150093	ENSMUSG00000025809
Uniprot	P05556	n/a
Refseq	NM_033668 (mRNA) NP_391988 (protein)	NM_010578 (mRNA) NP_034708 (protein)
Location	Chr 10: 33.23 - 33.29 Mb	Chr 8: 131.59 - 131.62 Mb
Pubmed search	[1]	[2]

[edit] Summary

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.