User:JonSDSUGrad/Sandbox/TEST5 IL8

From Wikipedia, the free encyclopedia

interleukin 8
PDB rendering based on 1icw.
Available structures: 1icw, 1ikl, 1ikm, 1il8, 1ilp, 1ilq, 1qe6, 2il8, 3il8
Identifiers
Symbol(s)	IL8; 3-10C; AMCF-I; CXCL8; GCP-1; GCP1; K60; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; SCYB8; TSG-1; b-ENAP
External IDs	OMIM: 146930 HomoloGene: 47937
Gene ontology Molecular Function: • angiogenesis • interleukin-8 receptor binding • protein binding • extracellular region • extracellular space • cell motility • chemotaxis • inflammatory response • immune response • cell cycle arrest • G-protein coupled receptor protein signaling pathway • intracellular signaling cascade • cell-cell signaling • chemokine activity • negative regulation of cell proliferation • calcium-mediated signaling • regulation of cell adhesion • neutrophil chemotaxis • neutrophil activation • regulation of retroviral genome replication • induction of positive chemotaxis
Orthologs
	Human	Mouse
Entrez	3576	n/a
Ensembl	ENSG00000169429	n/a
Uniprot	P10145	n/a
Refseq	NM_000584 (mRNA) NP_000575 (protein)	n/a (mRNA) n/a (protein)
Location	Chr 4: 74.83 - 74.83 Mb	n/a
Pubmed search	[1]	n/a

[edit] Summary

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.