User:JonSDSUGrad/Sandbox/TEST5 IL1B

From Wikipedia, the free encyclopedia

interleukin 1
PDB rendering based on 1hib.
Available structures: 1hib, 1i1b, 1iob, 1itb, 1l2h, 1s0l, 1t4q, 1too, 1tp0, 1twe, 1twm, 21bi, 2i1b, 2nvh, 31bi, 41bi, 4i1b, 5i1b, 6i1b, 7i1b, 9ilb
Identifiers
Symbol(s)	IL1B; IL-1; IL1-BETA; IL1F2
External IDs	OMIM: 147720 MGI: 96543 HomoloGene: 481
Gene ontology Molecular Function: • regulation of progression through cell cycle • fever • signal transducer activity • interleukin-1 receptor binding • protein binding • extracellular region • extracellular space • apoptosis • inflammatory response • immune response • signal transduction • cell-cell signaling • cell proliferation • negative regulation of cell proliferation • antimicrobial humoral response • neutrophil chemotaxis • positive regulation of chemokine biosynthetic process • positive regulation of interleukin-6 biosynthetic process • leukocyte migration
Orthologs
	Human	Mouse
Entrez	3553	16176
Ensembl	ENSG00000125538	ENSMUSG00000027398
Uniprot	P01584	n/a
Refseq	NM_000576 (mRNA) NP_000567 (protein)	NM_008361 (mRNA) NP_032387 (protein)
Location	Chr 2: 113.3 - 113.31 Mb	Chr 2: 129.06 - 129.06 Mb
Pubmed search	[1]	[2]

[edit] Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.