User:JonSDSUGrad/Sandbox/TEST5 IL10

From Wikipedia, the free encyclopedia

interleukin 10
PDB rendering based on 1ilk.
Available structures: 1ilk, 1inr, 1j7v, 1lk3, 1vlk, 1y6k, 1y6m, 1y6n, 2h24, 2ilk
Identifiers
Symbol(s)	IL10; CSIF; IL-10; IL10A; MGC126450; MGC126451; TGIF
External IDs	OMIM: 124092 MGI: 96537 HomoloGene: 478
Gene ontology Molecular Function: • cytokine activity • interleukin-10 receptor binding • protein binding • extracellular region • extracellular space • anti-apoptosis • inflammatory response • immune response • cytoplasmic sequestering of NF-kappaB • cell-cell signaling • hemopoiesis • B cell differentiation • leukocyte chemotaxis • T-helper 2 type immune response • B cell proliferation • negative regulation of T cell proliferation • defense response to bacterium • negative regulation of nitric oxide biosynthetic process • negative regulation of interferon-gamma biosynthetic process • regulation of isotype switching • negative regulation of MHC class II biosynthetic process • positive regulation of MHC class II biosynthetic process • negative regulation of interferon-alpha biosynthetic process
Orthologs
	Human	Mouse
Entrez	3586	16153
Ensembl	ENSG00000136634	ENSMUSG00000016529
Uniprot	P22301	n/a
Refseq	NM_000572 (mRNA) NP_000563 (protein)	NM_010548 (mRNA) NP_034678 (protein)
Location	Chr 1: 205.01 - 205.01 Mb	Chr 1: 132.85 - 132.85 Mb
Pubmed search	[1]	[2]

[edit] Summary

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.