User:JonSDSUGrad/Sandbox/TEST5 IGF1

From Wikipedia, the free encyclopedia


insulin-like growth factor 1 (somatomedin C)
PDB rendering based on 1bqt.
Available structures: 1bqt, 1gzr, 1gzy, 1gzz, 1h02, 1h59, 1imx, 1pmx, 1wqj, 2dsp, 2dsq, 2dsr, 2gf1, 3gf1, 3lri
Identifiers
Symbol(s) IGF1; IGFI
External IDs OMIM: 147440 MGI96432 HomoloGene515
Orthologs
Human Mouse
Entrez 3479 16000
Ensembl ENSG00000017427 ENSMUSG00000020053
Uniprot P01343 n/a
Refseq NM_000618 (mRNA)
NP_000609 (protein)
NM_010512 (mRNA)
NP_034642 (protein)
Location Chr 12: 101.31 - 101.4 Mb Chr 10: 87.29 - 87.36 Mb
Pubmed search [1] [2]

[edit] Summary

The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003).[supplied by OMIM]