User:JonSDSUGrad/Sandbox/TEST5 HIF1A

From Wikipedia, the free encyclopedia

hypoxia-inducible factor 1
PDB rendering based on 1h2k.
Available structures: 1h2k, 1h2l, 1h2m, 1l3e, 1l8c, 1lqb
Identifiers
Symbol(s)	HIF1A; HIF-1alpha; HIF1-ALPHA; MOP1; PASD8
External IDs	OMIM: 603348 MGI: 106918 HomoloGene: 1171
Gene ontology Molecular Function: • angiogenesis • response to hypoxia • neural crest cell migration • heart looping • RNA polymerase II transcription factor activity, enhancer binding • signal transducer activity • protein binding • nucleus • regulation of transcription, DNA-dependent • signal transduction • microtubule-based flagellum • cell differentiation • histone acetyltransferase binding • homeostatic process • regulation of apoptosis • positive regulation of transcription • positive regulation of transcription from RNA polymerase II promoter • protein heterodimerization activity
Orthologs
	Human	Mouse
Entrez	3091	15251
Ensembl	ENSG00000100644	ENSMUSG00000021109
Uniprot	Q16665	n/a
Refseq	NM_001530 (mRNA) NP_001521 (protein)	NM_010431 (mRNA) NP_034561 (protein)
Location	Chr 14: 61.23 - 61.28 Mb	Chr 12: 74.83 - 74.87 Mb
Pubmed search	[1]	[2]

[edit] Summary

Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.