User:JonSDSUGrad/Sandbox/TEST5 ESR1

From Wikipedia, the free encyclopedia

estrogen receptor 1
PDB rendering based on 1a52.
Available structures: 1a52, 1ere, 1err, 1g50, 1gwq, 1gwr, 1hcp, 1hcq, 1l2i, 1pcg, 1qkt, 1qku, 1r5k, 1sj0, 1uom, 1x7e, 1x7r, 1xp1, 1xp6, 1xp9, 1xpc, 1xqc, 1yim, 1yin, 1zky, 2ayr, 2b1v, 2b1z, 2b23, 2bj4, 2fai, 2g44, 2g5o, 2i0j, 2jf9, 2jfa, 2ouz, 2p15, 3erd, 3ert
Identifiers
Symbol(s)	ESR1; ER; DKFZp686N23123; ESR; ESRA; Era; NR3A1
External IDs	OMIM: 133430 MGI: 1352467 HomoloGene: 47906
Gene ontology Molecular Function: • DNA binding • transcription factor activity • steroid hormone receptor activity • receptor activity • steroid binding • protein binding • nucleus • cytoplasm • regulation of transcription, DNA-dependent • signal transduction • zinc ion binding • lipid binding • membrane • cell growth • chromatin remodeling complex • nitric-oxide synthase regulator activity • estrogen receptor activity • estrogen receptor signaling pathway • sequence-specific DNA binding • negative regulation of mitosis • metal ion binding
Orthologs
	Human	Mouse
Entrez	2099	13982
Ensembl	ENSG00000091831	ENSMUSG00000019768
Uniprot	P03372	n/a
Refseq	NM_000125 (mRNA) NP_000116 (protein)	XM_985634 (mRNA) XP_990728 (protein)
Location	Chr 6: 152.17 - 152.47 Mb	Chr 10: 5.34 - 5.73 Mb
Pubmed search	[1]	[2]

[edit] Summary

The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.[supplied by OMIM]