User:JonSDSUGrad/Sandbox/TEST5 EGFR

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epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog

PDB rendering based on 1ivo.

Available structures: 1ivo, 1m14, 1m17, 1mox, 1nql, 1xkk, 1yy9, 1z9i, 2gs2, 2gs6, 2gs7, 2itn, 2ito, 2itp, 2itq, 2itt, 2itu, 2itv, 2itw, 2itx, 2ity, 2itz, 2j5e, 2j5f, 2j6m

Identifiers

EGFR; ERBB; ERBB1; mENA

External IDs

OMIM: 131550 MGI: 95294 HomoloGene: 74545

Gene ontology
Molecular Function:	• nucleotide binding • ossification • double-stranded DNA binding • MAP/ERK kinase kinase activity • transmembrane receptor activity • epidermal growth factor receptor activity • ATP binding • extracellular space • intracellular • nucleus • cytoplasm • endosome • plasma membrane • response to stress • cell cycle • cell surface receptor linked signal transduction • epidermal growth factor receptor signaling pathway • phospholipase C activation • cell proliferation • integral to membrane • basolateral plasma membrane • cell-cell adhesion • transferase activity • AP-2 adaptor complex • endocytic vesicle • nitric-oxide synthase regulator activity • positive regulation of cell migration • positive regulation of phosphorylation • identical protein binding • calcium-dependent phospholipase A2 activation • positive regulation of MAPK activity • positive regulation of nitric oxide biosynthetic process • negative regulation of progression through cell cycle • protein amino acid autophosphorylation • protein heterodimerization activity • positive regulation of epithelial cell proliferation • regulation of peptidyl-tyrosine phosphorylation • regulation of nitric-oxide synthase activity • actin filament binding • protein insertion into membrane

Orthologs

Human

Mouse

ENSG00000146648

ENSMUSG00000020122

n/a

Refseq

NM_005228 (mRNA)
NP_005219 (protein)

NM_007912 (mRNA)
NP_031938 (protein)

Location

Chr 7: 55.05 - 55.24 Mb

Chr 11: 16.65 - 16.81 Mb

Pubmed search

Categories: Genes on chromosome 7 | Human proteins

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