User:JonSDSUGrad/Sandbox/TEST5 CASP3

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caspase 3
PDB rendering based on 1cp3.
Available structures: 1cp3, 1gfw, 1i3o, 1nme, 1nmq, 1nms, 1pau, 1qx3, 1re1, 1rhj, 1rhk, 1rhm, 1rhq, 1rhr, 1rhu, 2c1e, 2c2k, 2c2m, 2c2o, 2cdr, 2cjx, 2cjy, 2cnk, 2cnl, 2cnn, 2cno, 2dko, 2h5i, 2h5j, 2h65, 2j30, 2j31, 2j32, 2j33
Identifiers
Symbol(s)	CASP3; CPP32; CPP32B; SCA-1
External IDs	OMIM: 600636 MGI: 107739 HomoloGene: 37912
Gene ontology Molecular Function: • B cell homeostasis • release of cytochrome c from mitochondria • cyclin-dependent protein kinase inhibitor activity • protein binding • cytoplasm • DNA fragmentation during apoptosis • proteolysis • apoptosis • induction of apoptosis • heart development • sensory perception of sound • cysteine-type peptidase activity • induction of apoptosis via death domain receptors • induction of apoptosis by oxidative stress • response to UV • response to wounding • keratinocyte differentiation • caspase activity • negative regulation of B cell proliferation • T cell homeostasis • cell fate commitment • negative regulation of cyclin-dependent protein kinase activity • negative regulation of activated T cell proliferation
Orthologs
	Human	Mouse
Entrez	836	12367
Ensembl	ENSG00000164305	ENSMUSG00000031628
Uniprot	P42574	n/a
Refseq	NM_004346 (mRNA) NP_004337 (protein)	XM_991820 (mRNA) XP_996914 (protein)
Location	Chr 4: 185.79 - 185.81 Mb	Chr 8: 48.12 - 48.14 Mb
Pubmed search	[1]	[2]

[edit] Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.