User:JonSDSUGrad/Sandbox/TEST11 Vascular endothelial growth factor

From Wikipedia, the free encyclopedia


Vascular endothelial growth factor A, also known as VEGFA, is a human gene.

Vascular endothelial growth factor A
PDB rendering based on 1bj1.
Available structures: 1bj1, 1cz8, 1flt, 1kat, 1kmx, 1mjv, 1mkg, 1mkk, 1qty, 1tzh, 1tzi, 1vgh, 1vpf, 1vpp, 2fjg, 2fjh, 2vgh, 2vpf
Identifiers
Symbol(s) VEGFA; MGC70609; VEGF; VEGF-A; VPF
External IDs OMIM: 192240 MGI: 103178 HomoloGene: 2534
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7422 22339
Ensembl ENSG00000112715 ENSMUSG00000023951
Uniprot P15692 A0FKR4
Refseq NM_001025366 (mRNA)
NP_001020537 (protein)		 NM_001025250 (mRNA)
NP_001020421 (protein)
Location Chr 6: 43.85 - 43.86 Mb Chr 17: 45.48 - 45.5 Mb
Pubmed search [1] [2]

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternate transcriptional splice variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.[1]

[edit] References

  1. ^ Entrez Gene: VEGFA vascular endothelial growth factor A.

[edit] Further reading

  • Ferrara N, Gerber HP (2002). "The role of vascular endothelial growth factor in angiogenesis.". Acta Haematol. 106 (4): 148-56. PMID 11815711. 
  • Orpana A, Salven P (2003). "Angiogenic and lymphangiogenic molecules in hematological malignancies.". Leuk. Lymphoma 43 (2): 219-24. PMID 11999550. 
  • Afuwape AO, Kiriakidis S, Paleolog EM (2003). "The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis.". Histol. Histopathol. 17 (3): 961-72. PMID 12168808. 
  • de Bont ES, Neefjes VM, Rosati S, et al. (2003). "New vessel formation and aberrant VEGF/VEGFR signaling in acute leukemia: does it matter?". Leuk. Lymphoma 43 (10): 1901-9. PMID 12481883. 
  • Ria R, Roccaro AM, Merchionne F, et al. (2003). "Vascular endothelial growth factor and its receptors in multiple myeloma.". Leukemia 17 (10): 1961-6. doi:10.1038/sj.leu.2403076. PMID 14513045. 
  • Caldwell RB, Bartoli M, Behzadian MA, et al. (2004). "Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives.". Diabetes Metab. Res. Rev. 19 (6): 442-55. doi:10.1002/dmrr.415. PMID 14648803. 
  • Patan S (2004). "Vasculogenesis and angiogenesis.". Cancer Treat. Res. 117: 3-32. PMID 15015550. 
  • Machein MR, Plate KH (2004). "Role of VEGF in developmental angiogenesis and in tumor angiogenesis in the brain.". Cancer Treat. Res. 117: 191-218. PMID 15015562. 
  • Eremina V, Quaggin SE (2004). "The role of VEGF-A in glomerular development and function.". Curr. Opin. Nephrol. Hypertens. 13 (1): 9-15. PMID 15090854. 
  • Storkebaum E, Lambrechts D, Carmeliet P (2004). "VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection.". Bioessays 26 (9): 943-54. doi:10.1002/bies.20092. PMID 15351965. 
  • Ribatti D (2005). "The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review.". Br. J. Haematol. 128 (3): 303-9. doi:10.1111/j.1365-2141.2004.05291.x. PMID 15667531. 
  • Loureiro RM, D'Amore PA (2005). "Transcriptional regulation of vascular endothelial growth factor in cancer.". Cytokine Growth Factor Rev. 16 (1): 77-89. doi:10.1016/j.cytogfr.2005.01.005. PMID 15733833. 
  • Rini BI (2005). "VEGF-targeted therapy in metastatic renal cell carcinoma.". Oncologist 10 (3): 191-7. doi:10.1634/theoncologist.10-3-191. PMID 15793222. 
  • Herbst RS, Onn A, Sandler A (2005). "Angiogenesis and lung cancer: prognostic and therapeutic implications.". J. Clin. Oncol. 23 (14): 3243-56. doi:10.1200/JCO.2005.18.853. PMID 15886312. 
  • Pufe T, Kurz B, Petersen W, et al. (2006). "The influence of biomechanical parameters on the expression of VEGF and endostatin in the bone and joint system.". Ann. Anat. 187 (5-6): 461-72. PMID 16320826. 
  • Tong JP, Yao YF (2006). "Contribution of VEGF and PEDF to choroidal angiogenesis: a need for balanced expressions.". Clin. Biochem. 39 (3): 267-76. doi:10.1016/j.clinbiochem.2005.11.013. PMID 16409998. 
  • Lambrechts D, Carmeliet P (2007). "VEGF at the neurovascular interface: therapeutic implications for motor neuron disease.". Biochim. Biophys. Acta 1762 (11-12): 1109-21. doi:10.1016/j.bbadis.2006.04.005. PMID 16784838. 
  • Matsumoto T, Mugishima H (2006). "Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis.". J. Atheroscler. Thromb. 13 (3): 130-5. PMID 16835467. 
  • Bogaert E, Van Damme P, Van Den Bosch L, Robberecht W (2006). "Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases.". Muscle Nerve 34 (4): 391-405. doi:10.1002/mus.20609. PMID 16856151. 
  • Mercurio AM, Lipscomb EA, Bachelder RE (2006). "Non-angiogenic functions of VEGF in breast cancer.". Journal of mammary gland biology and neoplasia 10 (4): 283-90. doi:10.1007/s10911-006-9001-9. PMID 16924371. 
  • Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling.". Curr. Mol. Med. 6 (8): 831-41. PMID 17168735. 
  • Rini BI, Rathmell WK (2007). "Biological aspects and binding strategies of vascular endothelial growth factor in renal cell carcinoma.". Clin. Cancer Res. 13 (2 Pt 2): 741s-746s. doi:10.1158/1078-0432.CCR-06-2110. PMID 17255303.