User:JonSDSUGrad/Sandbox/TEST11 Retinoblastoma protein

From Wikipedia, the free encyclopedia

Retinoblastoma 1 (including osteosarcoma), also known as RB1, is a human gene.

Retinoblastoma 1 (including osteosarcoma)
PDB rendering based on 1ad6.
Available structures: 1ad6, 1gh6, 1gux, 1o9k, 2aze
Identifiers
Symbol(s)	RB1; OSRC; RB
External IDs	OMIM: 180200 MGI: 97874 HomoloGene: 272
Gene ontology Molecular Function: • molecular_function • transcription factor activity • transcription coactivator activity • transcription factor binding • transcription repressor activity • kinase binding • androgen receptor binding Cellular Component: • chromatin • nucleus • transcription factor complex • spindle Biological Process: • cell cycle checkpoint • G1/S transition of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • M phase • transcription • regulation of transcription, DNA-dependent • negative regulation of protein kinase activity • cell cycle • cell cycle arrest • negative regulation of cell proliferation • negative regulation of cell growth • androgen receptor signaling pathway • regulation of lipid kinase activity • positive regulation of transcription from RNA polymerase II promoter • striated muscle cell differentiation • cell division • G1 phase
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	5925	19645
Ensembl	ENSG00000139687	ENSMUSG00000022105
Uniprot	P06400	Q3UFM7
Refseq	NM_000321 (mRNA) NP_000312 (protein)	NM_009029 (mRNA) NP_033055 (protein)
Location	Chr 13: 47.78 - 47.95 Mb	Chr 14: 71.93 - 72.06 Mb
Pubmed search	[1]	[2]

Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.[supplied by OMIM]^[1]

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