User:JonSDSUGrad/Sandbox/TEST11 NFKB1

From Wikipedia, the free encyclopedia


Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), also known as NFKB1, is a human gene.

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
PDB rendering based on 1bfs.
Available structures: 1bfs, 1ikn, 1le5, 1le9, 1lei, 1nfi, 1nfk, 1ooa, 1svc, 1u36, 1u3j, 1u3y, 1u3z, 1u41, 1u42, 1vkx, 2dbf, 2i9t
Identifiers
Symbol(s) NFKB1; DKFZp686C01211; EBP-1; KBF1; MGC54151; NF-kappa-B; NFKB-p105; NFKB-p50
External IDs OMIM: 164011 MGI: 97312 HomoloGene: 2971
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4790 18033
Ensembl ENSG00000109320 ENSMUSG00000028163
Uniprot P19838 P25799
Refseq NM_003998 (mRNA)
NP_003989 (protein)		 NM_008689 (mRNA)
NP_032715 (protein)
Location Chr 4: 103.64 - 103.76 Mb Chr 3: 135.29 - 135.61 Mb
Pubmed search [1] [2]

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.[1]

[edit] References

  1. ^ Entrez Gene: NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105).

[edit] Further reading

  • Baldwin AS (1996). "The NF-kappa B and I kappa B proteins: new discoveries and insights.". Annu. Rev. Immunol. 14: 649-83. doi:10.1146/annurev.immunol.14.1.649. PMID 8717528. 
  • Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease.". Folia Biol. (Praha) 42 (5): 227-30. PMID 8997639. 
  • Chen F, Castranova V, Shi X, Demers LM (1999). "New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases.". Clin. Chem. 45 (1): 7-17. PMID 9895331. 
  • Bottex-Gauthier C, Pollet S, Favier A, Vidal DR (2002). "[The Rel/NF-kappa-B transcription factors: complex role in cell regulation]". Pathol. Biol. 50 (3): 204-11. PMID 11980335. 
  • Garg A, Aggarwal BB (2002). "Nuclear transcription factor-kappaB as a target for cancer drug development.". Leukemia 16 (6): 1053-68. doi:10.1038/sj.leu.2402482. PMID 12040437. 
  • Sun Z, Andersson R (2003). "NF-kappaB activation and inhibition: a review.". Shock 18 (2): 99-106. PMID 12166787. 
  • Mercurio AM (2003). "Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way.". Cancer Cell 3 (3): 201-2. PMID 12676577. 
  • Sun SC, Xiao G (2004). "Deregulation of NF-kappaB and its upstream kinases in cancer.". Cancer Metastasis Rev. 22 (4): 405-22. PMID 12884915. 
  • Kucharczak J, Simmons MJ, Fan Y, Gélinas C (2004). "To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis.". Oncogene 22 (56): 8961-82. doi:10.1038/sj.onc.1207230. PMID 14663476. 
  • Suh J, Rabson AB (2004). "NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon?". J. Cell. Biochem. 91 (1): 100-17. doi:10.1002/jcb.10729. PMID 14689584. 
  • Muthumani K, Desai BM, Hwang DS, et al. (2004). "HIV-1 Vpr and anti-inflammatory activity.". DNA Cell Biol. 23 (4): 239-47. doi:10.1089/104454904773819824. PMID 15142381. 
  • Schmitz ML, Mattioli I, Buss H, Kracht M (2005). "NF-kappaB: a multifaceted transcription factor regulated at several levels.". Chembiochem 5 (10): 1348-58. doi:10.1002/cbic.200400144. PMID 15457532. 
  • Pise-Masison CA, Brady JN (2006). "Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.". Front. Biosci. 10: 919-30. PMID 15569630. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87-94. PMID 15638726. 
  • Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle.". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353. 
  • Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation.". Cell Res. 15 (3): 143-9. doi:10.1038/sj.cr.7290279. PMID 15780175. 
  • Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses.". Indian J. Med. Res. 121 (4): 270-86. PMID 15817944. 
  • Muthumani K, Choo AY, Hwang DS, et al. (2006). "HIV-1 Vpr: enhancing sensitivity of tumors to apoptosis.". Current drug delivery 1 (4): 335-44. PMID 16305395. 
  • Courtois G, Smahi A (2006). "NF-kappaB-related genetic diseases.". Cell Death Differ. 13 (5): 843-51. doi:10.1038/sj.cdd.4401841. PMID 16397577. 
  • Mattson MP, Meffert MK (2006). "Roles for NF-kappaB in nerve cell survival, plasticity, and disease.". Cell Death Differ. 13 (5): 852-60. doi:10.1038/sj.cdd.4401837. PMID 16397579. 
  • Schmitz ML, Krappmann D (2006). "Controlling NF-kappaB activation in T cells by costimulatory receptors.". Cell Death Differ. 13 (5): 834-42. doi:10.1038/sj.cdd.4401845. PMID 16410801. 
  • Janssens S, Tschopp J (2006). "Signals from within: the DNA-damage-induced NF-kappaB response.". Cell Death Differ. 13 (5): 773-84. doi:10.1038/sj.cdd.4401843. PMID 16410802. 
  • Perkins ND, Gilmore TD (2006). "Good cop, bad cop: the different faces of NF-kappaB.". Cell Death Differ. 13 (5): 759-72. doi:10.1038/sj.cdd.4401838. PMID 16410803. 
  • Weil R, Israël A (2006). "Deciphering the pathway from the TCR to NF-kappaB.". Cell Death Differ. 13 (5): 826-33. doi:10.1038/sj.cdd.4401856. PMID 16439988. 
  • Kim HJ, Hawke N, Baldwin AS (2006). "NF-kappaB and IKK as therapeutic targets in cancer.". Cell Death Differ. 13 (5): 738-47. doi:10.1038/sj.cdd.4401877. PMID 16485028. 
  • Braun T, Carvalho G, Fabre C, et al. (2006). "Targeting NF-kappaB in hematologic malignancies.". Cell Death Differ. 13 (5): 748-58. doi:10.1038/sj.cdd.4401874. PMID 16498458. 
  • Bottero V, Withoff S, Verma IM (2006). "NF-kappaB and the regulation of hematopoiesis.". Cell Death Differ. 13 (5): 785-97. doi:10.1038/sj.cdd.4401888. PMID 16528384. 
  • Xiao G (2007). "Autophagy and NF-kappaB: fight for fate.". Cytokine Growth Factor Rev. 18 (3-4): 233-43. doi:10.1016/j.cytogfr.2007.04.006. PMID 17485237.