User:JonSDSUGrad/Sandbox/TEST11 Interleukin 8

From Wikipedia, the free encyclopedia


Interleukin 8, also known as IL8, is a human gene.

Interleukin 8
PDB rendering based on 1icw.
Available structures: 1icw, 1ikl, 1ikm, 1il8, 1ilp, 1ilq, 1qe6, 2il8, 3il8
Identifiers
Symbol(s) IL8; 3-10C; AMCF-I; CXCL8; GCP-1; GCP1; K60; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; SCYB8; TSG-1; b-ENAP
External IDs OMIM: 146930 HomoloGene: 47937
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3576 n/a
Ensembl ENSG00000169429 n/a
Uniprot P10145 n/a
Refseq NM_000584 (mRNA)
NP_000575 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 4: 74.83 - 74.83 Mb n/a
Pubmed search [1] n/a

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.[1]

[edit] References

  1. ^ Entrez Gene: IL8 interleukin 8.

[edit] Further reading

  • Baggiolini M, Clark-Lewis I (1992). "Interleukin-8, a chemotactic and inflammatory cytokine.". FEBS Lett. 307 (1): 97-101. PMID 1639201. 
  • Wahl SM, Greenwell-Wild T, Hale-Donze H, et al. (2000). "Permissive factors for HIV-1 infection of macrophages.". J. Leukoc. Biol. 68 (3): 303-10. PMID 10985244. 
  • Starckx S, Van den Steen PE, Wuyts A, et al. (2003). "Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization.". Leuk. Lymphoma 43 (2): 233-41. PMID 11999552. 
  • Smirnova MG, Kiselev SL, Gnuchev NV, et al. (2003). "Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion.". Eur. Cytokine Netw. 13 (2): 161-72. PMID 12101072. 
  • Struyf S, Proost P, Van Damme J (2004). "Regulation of the immune response by the interaction of chemokines and proteases.". Adv. Immunol. 81: 1-44. PMID 14711052. 
  • Chakravorty M, Ghosh A, Choudhury A, et al. (2004). "Ethnic differences in allele distribution for the IL8 and IL1B genes in populations from eastern India.". Hum. Biol. 76 (1): 153-9. PMID 15222686. 
  • Yuan A, Chen JJ, Yao PL, Yang PC (2006). "The role of interleukin-8 in cancer cells and microenvironment interaction.". Front. Biosci. 10: 853-65. PMID 15569594. 
  • Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines.". Mini reviews in medicinal chemistry 5 (12): 1093-101. PMID 16375755.