User:JonSDSUGrad/Sandbox/TEST11 IL1B

From Wikipedia, the free encyclopedia


Interleukin 1, beta, also known as IL1B, is a human gene.

Interleukin 1, beta
PDB rendering based on 1hib.
Available structures: 1hib, 1i1b, 1iob, 1itb, 1l2h, 1s0l, 1t4q, 1too, 1tp0, 1twe, 1twm, 21bi, 2i1b, 2nvh, 31bi, 41bi, 4i1b, 5i1b, 6i1b, 7i1b, 9ilb
Identifiers
Symbol(s) IL1B; IL-1; IL1-BETA; IL1F2
External IDs OMIM: 147720 MGI: 96543 HomoloGene: 481
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3553 16176
Ensembl ENSG00000125538 ENSMUSG00000027398
Uniprot P01584 Q2M4J6
Refseq NM_000576 (mRNA)
NP_000567 (protein)		 NM_008361 (mRNA)
NP_032387 (protein)
Location Chr 2: 113.3 - 113.31 Mb Chr 2: 129.06 - 129.06 Mb
Pubmed search [1] [2]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.[1]

[edit] References

  1. ^ Entrez Gene: IL1B interleukin 1, beta.

[edit] Further reading

  • Smirnova MG, Kiselev SL, Gnuchev NV, et al. (2003). "Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion.". Eur. Cytokine Netw. 13 (2): 161-72. PMID 12101072. 
  • Griffin WS, Mrak RE (2002). "Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease.". J. Leukoc. Biol. 72 (2): 233-8. PMID 12149413. 
  • Arend WP (2003). "The balance between IL-1 and IL-1Ra in disease.". Cytokine Growth Factor Rev. 13 (4-5): 323-40. PMID 12220547. 
  • Chakravorty M, Ghosh A, Choudhury A, et al. (2004). "Ethnic differences in allele distribution for the IL8 and IL1B genes in populations from eastern India.". Hum. Biol. 76 (1): 153-9. PMID 15222686. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87-94. PMID 15638726. 
  • Maruyama Y, Stenvinkel P, Lindholm B (2005). "Role of interleukin-1beta in the development of malnutrition in chronic renal failure patients.". Blood Purif. 23 (4): 275-81. doi:10.1159/000086012. PMID 15925866. 
  • Roy D, Sarkar S, Felty Q (2006). "Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells.". Front. Biosci. 11: 889-98. PMID 16146780. 
  • Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines.". Mini reviews in medicinal chemistry 5 (12): 1093-101. PMID 16375755. 
  • Prinz C, Schwendy S, Voland P (2006). "H pylori and gastric cancer: shifting the global burden.". World J. Gastroenterol. 12 (34): 5458-64. PMID 17006981. 
  • Kamangar F, Cheng C, Abnet CC, Rabkin CS (2007). "Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis.". Cancer Epidemiol. Biomarkers Prev. 15 (10): 1920-8. doi:10.1158/1055-9965.EPI-06-0267. PMID 17035400.