User:JonSDSUGrad/Sandbox/TEST11 HER2

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V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), also known as ERBB2, is a human gene.

V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
PDB rendering based on 1n8z.
Available structures: 1n8z, 1s78, 2a91
Identifiers
Symbol(s)	ERBB2; HER-2; HER-2/neu; HER2; NEU; NGL; TKR1; c-erb B2
External IDs	OMIM: 164870 MGI: 95410 HomoloGene: 3273
Gene ontology Molecular Function: • nucleotide binding • protein-tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • receptor activity • epidermal growth factor receptor activity • iron ion binding • ATP binding • electron carrier activity • transferase activity • identical protein binding • ErbB-3 class receptor binding • protein heterodimerization activity Cellular Component: • extracellular region • cytoplasm • plasma membrane • membrane • integral to membrane • apical plasma membrane Biological Process: • electron transport • protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • peripheral nervous system development • heart development • cell proliferation • mammary gland development • myelination • positive regulation of MAPK activity • regulation of angiogenesis • phosphoinositide-mediated signaling • positive regulation of epithelial cell proliferation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2064	13866
Ensembl	ENSG00000141736	ENSMUSG00000062312
Uniprot	P04626	Q80Y89
Refseq	NM_001005862 (mRNA) NP_001005862 (protein)	NM_001003817 (mRNA) NP_001003817 (protein)
Location	Chr 17: 35.1 - 35.14 Mb	Chr 11: 98.23 - 98.25 Mb
Pubmed search	[1]	[2]

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.^[1]

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