User:JonSDSUGrad/Sandbox/TEST11 Estrogen receptor

From Wikipedia, the free encyclopedia


Estrogen receptor 1, also known as ESR1, is a human gene.

Estrogen receptor 1
PDB rendering based on 1a52.
Available structures: 1a52, 1ere, 1err, 1g50, 1gwq, 1gwr, 1hcp, 1hcq, 1l2i, 1pcg, 1qkt, 1qku, 1r5k, 1sj0, 1uom, 1x7e, 1x7r, 1xp1, 1xp6, 1xp9, 1xpc, 1xqc, 1yim, 1yin, 1zky, 2ayr, 2b1v, 2b1z, 2b23, 2bj4, 2fai, 2g44, 2g5o, 2i0j, 2jf9, 2jfa, 2ouz, 2p15, 3erd, 3ert
Identifiers
Symbol(s) ESR1; ER; DKFZp686N23123; ESR; ESRA; Era; NR3A1
External IDs OMIM: 133430 MGI: 1352467 HomoloGene: 47906
Orthologs
Human Mouse
Entrez 2099 13982
Ensembl ENSG00000091831 ENSMUSG00000019768
Uniprot P03372 Q3UT58
Refseq NM_000125 (mRNA)
NP_000116 (protein)		 XM_985634 (mRNA)
XP_990728 (protein)
Location Chr 6: 152.17 - 152.47 Mb Chr 10: 5.34 - 5.73 Mb
Pubmed search [1] [2]

The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.[supplied by OMIM][1]

[edit] References

  1. ^ Entrez Gene: ESR1 estrogen receptor 1.

[edit] Further reading

  • McDonnell DP, Norris JD (2002). "Connections and regulation of the human estrogen receptor.". Science 296 (5573): 1642-4. doi:10.1126/science.1071884. PMID 12040178. 
  • Simoncini T, Fornari L, Mannella P, et al. (2003). "Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system. Interaction of estrogen receptor alpha with phosphatidylinositol 3-OH kinase.". Steroids 67 (12): 935-9. PMID 12398989. 
  • Lannigan DA (2003). "Estrogen receptor phosphorylation.". Steroids 68 (1): 1-9. PMID 12475718. 
  • Herrington DM (2003). "Role of estrogen receptor-alpha in pharmacogenetics of estrogen action.". Curr. Opin. Lipidol. 14 (2): 145-50. doi:10.1097/01.mol.0000064045.68936.23. PMID 12642782. 
  • Tanaka Y, Sasaki M, Kaneuchi M, et al. (2004). "Estrogen receptor alpha polymorphisms and renal cell carcinoma--a possible risk.". Mol. Cell. Endocrinol. 202 (1-2): 109-16. PMID 12770739. 
  • Ali S, Coombes RC (2004). "Estrogen receptor alpha in human breast cancer: occurrence and significance.". Journal of mammary gland biology and neoplasia 5 (3): 271-81. PMID 14973389. 
  • Olsson H (2004). "Estrogen receptor content in malignant breast tumors in men--a review.". Journal of mammary gland biology and neoplasia 5 (3): 283-7. PMID 14973390. 
  • Surmacz E, Bartucci M (2005). "Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer.". J. Exp. Clin. Cancer Res. 23 (3): 385-94. PMID 15595626. 
  • Evinger AJ, Levin ER (2005). "Requirements for estrogen receptor alpha membrane localization and function.". Steroids 70 (5-7): 361-3. doi:10.1016/j.steroids.2005.02.015. PMID 15862818. 
  • Wang CL, Tang XY, Chen WQ, et al. (2007). "Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis.". Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 18 (3): 295-305. doi:10.1007/s00198-006-0239-2. PMID 17089081.