User:JonSDSUGrad/Sandbox/TEST11 Epidermal growth factor receptor

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Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), also known as EGFR, is a human gene.

Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
PDB rendering based on 1ivo.
Available structures: 1ivo, 1m14, 1m17, 1mox, 1nql, 1xkk, 1yy9, 1z9i, 2gs2, 2gs6, 2gs7, 2itn, 2ito, 2itp, 2itq, 2itt, 2itu, 2itv, 2itw, 2itx, 2ity, 2itz, 2j5e, 2j5f, 2j6m
Identifiers
Symbol(s) EGFR; ERBB; ERBB1; mENA
External IDs OMIM: 131550 MGI: 95294 HomoloGene: 74545
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1956 13649
Ensembl ENSG00000146648 ENSMUSG00000020122
Uniprot P00533 Q3TQS6
Refseq NM_005228 (mRNA)
NP_005219 (protein)		 NM_007912 (mRNA)
NP_031938 (protein)
Location Chr 7: 55.05 - 55.24 Mb Chr 11: 16.65 - 16.81 Mb
Pubmed search [1] [2]


[edit] Further reading

  • Carpenter G (1987). "Receptors for epidermal growth factor and other polypeptide mitogens.". Annu. Rev. Biochem. 56: 881-914. doi:10.1146/annurev.bi.56.070187.004313. PMID 3039909. 
  • Boonstra J, Rijken P, Humbel B, et al. (1995). "The epidermal growth factor.". Cell Biol. Int. 19 (5): 413-30. PMID 7640657. 
  • Carpenter G (2000). "The EGF receptor: a nexus for trafficking and signaling.". Bioessays 22 (8): 697-707. doi:10.1002/1521-1878(200008)22:8<697::AID-BIES3>3.0.CO;2-1. PMID 10918300. 
  • Filardo EJ (2002). "Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer.". J. Steroid Biochem. Mol. Biol. 80 (2): 231-8. PMID 11897506. 
  • Tiganis T (2002). "Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor.". IUBMB Life 53 (1): 3-14. PMID 12018405. 
  • Di Fiore PP, Scita G (2002). "Eps8 in the midst of GTPases.". Int. J. Biochem. Cell Biol. 34 (10): 1178-83. PMID 12127568. 
  • Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications.". Eur. J. Biochem. 269 (15): 3619-31. PMID 12153558. 
  • Leu TH, Maa MC (2004). "Functional implication of the interaction between EGF receptor and c-Src.". Front. Biosci. 8: s28-38. PMID 12456372. 
  • Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845-67. PMID 12488461. 
  • Kari C, Chan TO, Rocha de Quadros M, Rodeck U (2003). "Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage.". Cancer Res. 63 (1): 1-5. PMID 12517767. 
  • Bonaccorsi L, Muratori M, Carloni V, et al. (2003). "Androgen receptor and prostate cancer invasion.". Int. J. Androl. 26 (1): 21-5. PMID 12534934. 
  • Reiter JL, Maihle NJ (2003). "Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta.". Ann. N. Y. Acad. Sci. 995: 39-47. PMID 12814937. 
  • Adams TE, McKern NM, Ward CW (2005). "Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor.". Growth Factors 22 (2): 89-95. PMID 15253384. 
  • Ferguson KM (2005). "Active and inactive conformations of the epidermal growth factor receptor.". Biochem. Soc. Trans. 32 (Pt 5): 742-5. doi:10.1042/BST0320742. PMID 15494003. 
  • Chao C, Hellmich MR (2005). "Bi-directional signaling between gastrointestinal peptide hormone receptors and epidermal growth factor receptor.". Growth Factors 22 (4): 261-8. doi:10.1080/08977190412331286900. PMID 15621729. 
  • Carlsson J, Ren ZP, Wester K, et al. (2006). "Planning for intracavitary anti-EGFR radionuclide therapy of gliomas. Literature review and data on EGFR expression.". J. Neurooncol. 77 (1): 33-45. doi:10.1007/s11060-005-7410-z. PMID 16200342. 
  • Scartozzi M, Pierantoni C, Berardi R, et al. (2006). "Epidermal growth factor receptor: a promising therapeutic target for colorectal cancer.". Anal. Quant. Cytol. Histol. 28 (2): 61-8. PMID 16637508. 
  • Prudkin L, Wistuba II (2006). "Epidermal growth factor receptor abnormalities in lung cancer. Pathogenetic and clinical implications.". Annals of diagnostic pathology 10 (5): 306-15. doi:10.1016/j.anndiagpath.2006.06.011. PMID 16979526. 
  • Ahmed SM, Salgia R (2007). "Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer.". Respirology 11 (6): 687-92. doi:10.1111/j.1440-1843.2006.00887.x. PMID 17052295. 
  • Zhang X, Chang A (2007). "Somatic mutations of the epidermal growth factor receptor and non-small-cell lung cancer.". J. Med. Genet. 44 (3): 166-72. doi:10.1136/jmg.2006.046102. PMID 17158592. 
  • Cohenuram M, Saif MW (2007). "Epidermal growth factor receptor inhibition strategies in pancreatic cancer: past, present and the future.". JOP 8 (1): 4-15. PMID 17228128. 
  • Mellinghoff IK, Cloughesy TF, Mischel PS (2007). "PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors.". Clin. Cancer Res. 13 (2 Pt 1): 378-81. doi:10.1158/1078-0432.CCR-06-1992. PMID 17255257. 
  • Nakamura JL (2007). "The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications.". Expert Opin. Ther. Targets 11 (4): 463-72. doi:10.1517/14728222.11.4.463. PMID 17373877.