User:JonSDSUGrad/Sandbox/TEST11 CD29

From Wikipedia, the free encyclopedia

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), also known as ITGB1, is a human gene.

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

Identifiers

Symbol(s)

ITGB1; CD29; FNRB; GPIIA; MDF2; MSK12; VLAB

External IDs

OMIM: 135630 MGI: 96610 HomoloGene: 22999

Gene ontology
Molecular Function:	• receptor activity • protein binding • identical protein binding • protein heterodimerization activity
Cellular Component:	• ruffle • endoplasmic reticulum • integrin complex • membrane • integral to membrane
Biological Process:	• cellular defense response • cell adhesion • homophilic cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • multicellular organismal development • cell migration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002211 (mRNA)
NP_002202 (protein)

NM_010578 (mRNA)
NP_034708 (protein)

Location

Chr 10: 33.23 - 33.29 Mb

Chr 8: 131.59 - 131.62 Mb

Pubmed search

[1]

[2]

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.^[1]

[edit] References

^ Entrez Gene: ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12).

[edit] Further reading

Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization.". Bioessays 23 (7): 628-39. doi:10.1002/bies.1088. PMID 11462216.
Armulik A (2002). "Splice variants of human beta 1 integrins: origin, biosynthesis and functions.". Front. Biosci. 7: d219-27. PMID 11779688.
Brakebusch C, FÃ¤ssler R (2006). "beta 1 integrin function in vivo: adhesion, migration and more.". Cancer Metastasis Rev. 24 (3): 403-11. doi:10.1007/s10555-005-5132-5. PMID 16258728.