User:JonSDSUGrad/Sandbox/PPARG

From Wikipedia, the free encyclopedia

peroxisome proliferator-activated receptor gamma
PDB rendering based on 1fm6.
Available structures: 1fm6, 1fm9, 1i7i, 1k74, 1knu, 1nyx, 1prg, 1rdt, 1wm0, 1zeo, 1zgy, 2ath, 2f4b, 2fvj, 2g0g, 2g0h, 2gtk, 2hfp, 2i4j, 2i4p, 2i4z, 2om9, 2prg, 3prg, 4prg
Identifiers
Symbol(s)	PPARG; NR1C3; PPARG1; PPARG2
External IDs	OMIM: 601487 MGI: 97747 HomoloGene: 7899
Gene ontology Molecular Function: • negative regulation of transcription from RNA polymerase II promoter • transcription factor activity • steroid hormone receptor activity • protein binding • nucleus • cytosol • generation of precursor metabolites and energy • transcription • regulation of transcription, DNA-dependent • lipid metabolic process • signal transduction • response to nutrient • zinc ion binding • transcription activator activity • transcription repressor activity • epithelial cell differentiation • sequence-specific DNA binding • cell fate commitment • regulation of fat cell differentiation • positive regulation of transcription • positive regulation of transcription from RNA polymerase II promoter • metal ion binding • white fat cell differentiation
Orthologs
	Human	Mouse
Entrez	5468	19016
Ensembl	ENSG00000132170	ENSMUSG00000000440
Uniprot	P37231	n/a
Refseq	NM_005037 (mRNA) NP_005028 (protein)	NM_011146 (mRNA) NP_035276 (protein)
Location	Chr 3: 12.3 - 12.45 Mb	Chr 6: 115.39 - 115.46 Mb
Pubmed search	[1]	[2]

[edit] Summary

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. ^[1]

[edit] References

1. ^ Entrez Gene: PPARG peroxisome proliferator-activated receptor gamma. Retrieved on 2007-08-13.